Quantification of Regional Cerebral Blood Flow Using Diffusion Imaging With Phase Contrast
Quantification of Regional Cerebral Blood Flow Using Diffusion Imaging With Phase Contrast
复制标题
使用相衬扩散成像定量局部脑血流
DOI：
10.1002/jmri.27735
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发表时间：
2021
影响因子：
4.4
通讯作者：
Kobayashi Satoshi
中科院分区：
文献类型：
--
作者：
Ohno Naoki;Miyati Tosiaki;Sugita Fumiki;Nanbu Genki;Makino Yuki;Alperin Noam;Gabata Toshifumi;Kobayashi Satoshi
背景三指数扩散分析得到的灌注相关扩散系数与动脉自旋标记(ASL)方法评估的局部脑血流量(RCBF)密切相关。目的使用一种新的具有相位对比的扩散成像方法(DPC)以非侵入性的方式获得rCBF，该方法利用来自相位对比(PC)MRI的总CBF将与灌注相关的扩散系数转换为rCBF值。场强/序列A 3.0 T、单次激发多值扩散回波平面成像(0~3 000 S/mm~2)、PC-MRI、脉冲连续ASL和3DT1加权快速场回波。比较DPC和ASL两种方法的脑血流量及其在灰质和白质的相关性。将GM和WM的rCBF和GM/WM比值与[150]-水正电子发射断层扫描(15O-H2O PET)的文献值进行比较。统计检验采用Spearman相关系数和Wilcoxon符号等级检验。结果在GM组， 与ASL的rCBF呈显著正相关(R=0.90)，而在西医组两者相关性较差(R=0.09)。用DPC得到的GM和WM的rCBF和GM/WM比值与用15O-H2O PET评估的文献值一致。在GM和WM中，DPC获得的rCBF值显著高于ASL。数据结论DPC能够无创性地定量rCBF。
BackgroundThe perfusion‐related diffusion coefficient obtained from triexponential diffusion analysis is closely correlated with regional cerebral blood flow (rCBF), as assessed by arterial spin labeling (ASL) methods. However, this provides only a semiquantitative measure of rCBF, thereby making absolute rCBF quantification challenging.PurposeTo obtain rCBF in a noninvasive manner using a novel diffusion imaging method with phase contrast (DPC), in which the total CBF from phase‐contrast (PC) MRI was utilized to convert perfusion‐related diffusion coefficients to rCBF values.Study TypeProspective.SubjectsEleven healthy volunteers (nine men and two women; mean age, 23.9 years) participated in this study.Field Strength/SequenceA 3.0 T, single‐shot diffusion echo‐planar imaging with multipleb‐values (0–3000 s/mm2), PC‐MRI, pulsed continuous ASL, and 3D T1‐weighted fast field echo.AssessmentrCBF and its correlations in the gray matter (GM) and white matter (WM) were compared between DPC and ASL methods. rCBF in the GM and WM and the GM/WM ratio were compared with the literature values obtained using [15O]‐water positron emission tomography (15O‐H2O PET).Statistical TestsSpearman's correlation coefficient and Wilcoxon signed‐rank test were used. Significance was set atP< 0.05.ResultsA significant positive correlation between DPC and ASL in terms of rCBF was observed in GM (R= 0.9), whereas the correlation between the two methods was poor in WM (R= 0.09). The rCBF in GM and WM and the GM/WM ratio obtained using DPC were consistent with the literature values assessed using15O‐H2O PET. The rCBF value obtained using DPC was significantly higher in the GM and WM than that using ASL.Data ConclusionDPC enabled noninvasive quantification of rCBF.Evidence Level2Technical EfficacyStage 1.