Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research.
Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research.
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DOI：
10.1007/s13668-013-0052-4
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发表时间：
2013-12
影响因子：
4.9
通讯作者：
Hu FB
中科院分区：
文献类型：
--
作者：
Cornelis MC;Hu FB
系统流行病学应用于营养领域有可能为更全面地研究特定食物对健康的影响提供新的机制和方法。人为干预和基于人群的研究已经确定了i)与几种营养相关特征相关的常见遗传因素和ii)改变与炎症、脂质代谢和/或肠道微生物代谢相关的基因表达和蛋白质及代谢物水平的饮食因素，这些结果与代谢性疾病高度相关。应用于2型糖尿病和相关疾病的系统级工具揭示了饮食可能改变的新途径，从而为营养调查提供了额外的机会。展望未来，利用现有的大型前瞻性研究资源，在这些研究中，生物样本已被存档，饮食和生活方式已在个体中反复测量，这将使系统级数据得以整合，其结果将改善用于预防和治疗疾病的个性化最佳营养。
Systems epidemiology applied to the field of nutrition has potential to provide new insight into underlying mechanisms and ways to study the health effects of specific foods more comprehensively. Human intervention and population-based studies have identified i) common genetic factors associated with several nutrition-related traits and ii) dietary factors altering the expression of genes and levels of proteins and metabolites related to inflammation, lipid metabolism and/or gut microbial metabolism, results of high relevance to metabolic disease. System-level tools applied type 2 diabetes and related conditions have revealed new pathways that are potentially modified by diet and thus offer additional opportunities for nutritional investigations. Moving forward, harnessing the resources of existing large prospective studies within which biological samples have been archived and diet and lifestyle have been measured repeatedly within individual will enable systems-level data to be integrated, the outcome of which will be improved personalized optimal nutrition for prevention and treatment of disease.