Oscillatory changes in muscle lipoprotein lipase activity of fed and starved rats.
Oscillatory changes in muscle lipoprotein lipase activity of fed and starved rats.
复制标题
进食和饥饿大鼠肌肉脂蛋白脂肪酶活性的振荡变化。
DOI：
10.1152/ajpendo.1977.233.4.e316
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
J. Borensztajn
中科院分区：
文献类型：
--
作者：
T. Kotlar;J. Borensztajn
脂蛋白脂肪酶活性测定在短时间内正常和链脲佐菌素治疗的糖尿病大鼠随意喂养或剥夺食物的心脏和骨骼肌。在随意进食的正常动物中，心脏、横膈膜、比目鱼肌和四头肌快颤红色纤维的脂蛋白脂肪酶活性表现出节律性振荡，这似乎与动物的夜间进食习惯相一致。白天（上午7点至下午7点），当大鼠的食物消耗量大大减少时，所有肌肉中的脂蛋白脂肪酶活性增加，随后在夜间下降到基础水平。在自由进食的糖尿病大鼠肌肉中观察到脂蛋白脂酶活性的类似振荡变化。然而，在正常大鼠剥夺食物，肌肉脂蛋白脂酶活性的振荡变化没有消除，并持续至少48小时。在糖尿病大鼠饥饿48小时期间，肌肉脂蛋白脂酶活性的振荡变化显着改变。在所有动物中，肌肉脂蛋白脂肪酶活性与血浆胰高血糖素水平无关。
Lipoprotein lipase activity was measured at short time intervals in cardiac and skeletal muscles of normal and streptozotocin-treated diabetic rats fed ad libitum or deprived of food. In normal animals fed ad libitum, lipoprotein lipase activities of heart, diaphragm, soleus, and fast-twitch red fibers of the quadriceps muscle showed rhythmic oscillations that appeared to coincide with the nocturnal feeding habits of the animals. During the day (7 A.M. to 7 P.M.), when food consumption by the rats was greatly reduced, lipoprotein lipase activity in all muscles increased, followed by a decline to basal levels during the night. Similar oscillatory changes in lipoprotein lipase activity were observed in the muscles of diabetic rats fed ad libitum. In normal rats deprived of food, however, the oscillatory changes in muscle lipoprotein lipase activity were not abolished and persisted for at least 48 h. In diabetic rats starved during a 48-h period, the oscillatory changes in muscle lipoprotein lipase activity were markedly altered. In all animals, muscle lipoprotein lipase activities were not correlated to plasma glucagon levels.