The hippocampal engram maps experience but not place
The hippocampal engram maps experience but not place
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DOI：
10.1126/science.aat5397
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发表时间：
2018-07-27
期刊：
影响因子：
56.9
通讯作者：
McHugh, Thomas J.
中科院分区：
文献类型：
--
作者：
Tanaka, Kazumasa Z.;He, Hongshen;McHugh, Thomas J.
情节记忆是由稀疏的海马神经元群体编码的。在小鼠身上，对这一记忆印记的光遗传操作证实，这些神经元是记忆回忆所必需的，并诱导记忆回忆。然而，人们对它们在体内的活动或在记忆中的确切作用知之甚少。我们发现，在记忆编码过程中，只有一小部分CA1位置细胞作为印记神经元发挥功能，其区别在于发射以theta频率起搏的重复爆发。在记忆回忆过程中，这些神经元保持高度的语境特异性，但表现出对其位置区域的优先重新映射。这些数据表明，不同的海马区集合分离了精确的空间编码和上下文索引，并表明海马区编码图作为记忆内容的指数。
Episodic memories are encoded by a sparse population of hippocampal neurons. In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We found that during memory encoding, only a fraction of CA1 place cells function as engram neurons, distinguished by firing repetitive bursts paced at the theta frequency. During memory recall, these neurons remained highly context specific, yet demonstrated preferential remapping of their place fields. These data demonstrate a dissociation of precise spatial coding and contextual indexing by distinct hippocampal ensembles and suggest that the hippocampal engram serves as an index of memory content.