Spike frequency adaptation affects the synchronization properties of networks of cortical oscillators
Spike frequency adaptation affects the synchronization properties of networks of cortical oscillators
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DOI：
10.1162/089976698300017511
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发表时间：
1998-05-15
影响因子：
2.9
通讯作者：
Bower, JM
中科院分区：
文献类型：
--
作者：
Crook, SM;Ermentrout, GB;Bower, JM
在皮层的许多区域中的振荡具有共同的时间特征，其中主频率集中在40 Hz（伽马）频率范围和5-10 Hz（θ）频率范围周围。实验结果还揭示了空间同步振荡，这是刺激依赖性的（Gray & Singer，1987; Gray，Konig，Engel，& Singer，1989; Engel，Konig，Kreiter，Schillen，& Singer，1992）。这种节律性活动表明，神经群体的一致性是皮质动力学的一个重要特征（Gray，1994）。使用模拟和理论耦合振荡器的方法，我们表明，尖峰频率适应看到许多锥体细胞中起着微妙的，但重要的作用，在动态的皮层网络。如果没有适应，模型锥体细胞之间的兴奋性连接就会被破坏。然而，与适应相关的缓慢过程鼓励稳定的同步行为。
Oscillations in many regions of the cortex have common temporal characteristics with dominant frequencies centered around the 40 Hz (gamma) frequency range and the 5-10 Hz (theta) frequency range. Experimental results also reveal spatially synchronous oscillations, which are stimulus dependent (Gray & Singer,1987; Gray, Konig, Engel, & Singer, 1989; Engel, Konig, Kreiter, Schillen, & Singer, 1992). This rhythmic activity suggests that the coherence of neural populations is a crucial feature of cortical dynamics (Gray, 1994). Using both simulations and a theoretical coupled oscillator approach, we demonstrate that the spike frequency adaptation seen in many pyramidal cells plays a subtle but important role in the dynamics of cortical networks. Without adaptation, excitatory connections among model pyramidal cells are desynchronizing. However, the slow processes associated with adaptation encourage stable synchronous behavior.