A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines
A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines
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DOI：
10.1021/acs.orglett.5b01783
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发表时间：
2015-08-07
期刊：
影响因子：
5.2
通讯作者：
Johnston, Jeffrey N.
中科院分区：
文献类型：
--
作者：
Danneman, Michael W.;Hong, Ki Bum;Johnston, Jeffrey N.
乙烯基氨基吡啶的操作简单且无金属的分子间/分子内氧化二胺化是进入所有四个氮杂吲哚啉杂环家族的共同途径。3-氨基氮杂吲哚啉是通过邻乙烯基N-甲苯磺酰基苯胺与富含电子的胺反应，使用苯基碘二乙酸酯（PIDA）和碘化物添加剂形成的。
An operationally straightforward and metal-free inter-/intramolecular oxidative diamination of vinyl amino-pyridines is a Common gateway to access all four azaindoline heterocycle families. 3-Amino azaindolines are formed by the reaction of ortho-vinyl N-tosyl anilines with election-rich amines, using phenyliododiaceate (PIDA) and an iodide additive.