Cadmium stress: an oxidative challenge
Cadmium stress: an oxidative challenge
复制标题
DOI：
10.1007/s10534-010-9329-x
复制
发表时间：
2010-10-01
期刊：
影响因子：
3.5
通讯作者：
Smeets, Karen
中科院分区：
文献类型：
--
作者：
Cuypers, Ann;Plusquin, Michelle;Smeets, Karen
在细胞水平上，镉（Cd）诱导损伤和修复过程，其中细胞氧化还原状态起关键作用。由于Cd不具有氧化活性，不能直接产生活性氧（ROS），但Cd诱导的氧化应激是多项研究中观察到的普遍现象。本文综述了不同Cd环境下生物体内Cd诱导的ROS生成和抗氧化防御的研究进展。此外，讨论了cd诱导的氧化挑战，重点是损伤和信号作为下游反应。通过收集这些数据，我们可以清楚地看到，氧化应激相关的反应在Cd胁迫期间受到影响，但不同研究之间观察到的明显差异表明，有必要增加我们对Cd胁迫下ROS时空特征的了解。这一信息对于揭示cd诱导的氧化应激在多种条件下对下游反应的调节中的确切作用至关重要。
At the cellular level, cadmium (Cd) induces both damaging and repair processes in which the cellular redox status plays a crucial role. Being not redox-active, Cd is unable to generate reactive oxygen species (ROS) directly, but Cd-induced oxidative stress is a common phenomenon observed in multiple studies. The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes. Moreover, the Cd-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses. Gathering these data, it was clear that oxidative stress related responses are affected during Cd stress, but the apparent discrepancies observed in between the different studies points towards the necessity to increase our knowledge on the spatial and temporal ROS signature under Cd stress. This information is essential in order to reveal the exact role of Cd-induced oxidative stress in the modulation of downstream responses under a diverse array of conditions.