Involvement of Fcα/μR (CD351) in autoantibody production
Involvement of Fcα/μR (CD351) in autoantibody production
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Fcα/μR (CD351) 参与自身抗体的产生
DOI：
10.1016/j.molimm.2013.10.002
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发表时间：
2013
期刊：
影响因子：
3.6
通讯作者：
Shibuya A
中科院分区：
文献类型：
--
作者：
Yoshizawa Y;Honda S;Shibuya A
抗体通过与免疫细胞上表达的Fc受体结合来发挥各种免疫应答。尽管一些报道已经证明IgM阻止自身抗体的产生，但IgM Fc受体的作用在很大程度上是未知的。为了分析Fcα/μR（CD 351）（一种在B细胞和滤泡树突状细胞（FDCs）上表达的IgM和伊加的Fc受体）在IgM介导的自身抗体产生抑制中的参与，我们在MRL/MpJ-Faslpr/lpr背景下产生Fcα/μR缺陷小鼠，（Fcamr-/-Faslpr/lpr）小鼠Fcamr-/-Faslpr/lpr小鼠显示出针对双链（ds）DNA的IgG自身抗体的显著较低滴度，Fcamr +/+Faslpr/lpr小鼠血清中组蛋白和心磷脂的水平高于Fcamr +/+Faslpr/lpr小鼠。此外，与Fcamr +/+ Faslpr/lpr小鼠相比，Fcamr −/−Faslpr/lpr小鼠在28、32和40周龄时显示出更高的存活率。这些结果表明，Fcα/μR增强而非抑制自身抗体的产生。
Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Faslpr/lpr(Fcamr−/−Faslpr/lpr) mice.Fcamr−/−Faslpr/lprmice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than didFcamr+/+Faslpr/lprmice. Moreover,Fcamr−/−Faslpr/lprmice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared withFcamr+/+Faslpr/lprmice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.