Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time
Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time
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DOI：
10.1016/0014-5793(96)00452-8
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发表时间：
1996-05-20
期刊：
影响因子：
3.5
通讯作者：
Zhu, GZ
中科院分区：
文献类型：
--
作者：
Uster, PS;Allen, TM;Zhu, GZ
MPEG（1900）-DSPE从胶束相转移到预形成的脂质体赋予否则快速清除的脂质组合物长的体内循环半衰期。MPEG（1900）-DSPE以时间和温度依赖性方式有效且快速地转移。和药代动力学参数，如分布相半衰期，由于生物学属性（脂质体清除率）可以通过插入过程改变，它提出了一种简单且经济的方式来赋予各种脂质体递送系统位点特异性靶向，该方法也是直接测量这种缀合物的“刷”厚度的方便方式。
Transfer of MPEG(1900)-DSPE from micellar phase to pre-formed liposomes imparts long in vivo circulation half-life to an otherwise rapidly cleared lipid composition, MPEG(1900)-DSPE transfers efficiently and quickly in a time and temperature dependent manner, There is negligible content leakage and a strong correlation between assayed mol% MPEG(1900)-DSPE, liposome diameter increase, and pharmacokinetic parameters such as distribution phase half-life, Since a biological attribute (liposome clearance rate) can be modified by the insertion process, it suggests a simple and economical way to impart site-specific targeting to a variety of liposome delivery systems, This method is also a convenient way to measure the 'brush' thickness of such conjugates directly.