Immunologic Factors in Human Milk and Disease Prevention in the Preterm Infant.
Immunologic Factors in Human Milk and Disease Prevention in the Preterm Infant.
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DOI：
10.1007/s40124-013-0028-2
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发表时间：
2013-12
影响因子：
1.9
通讯作者：
Walker, W Allan
中科院分区：
文献类型：
--
作者：
Gregory, Katherine E;Walker, W Allan
暴露于母乳中发现的免疫因子已被证明可以补偿早产儿特有的不成熟免疫系统。用母乳喂养早产儿不仅可以防止疾病发病，并在短期内确保最佳的营养来源，而且还有助于确保长期健康的免疫反应的发展。在这里，我们回顾了母乳中发现的生物活性分子的选择的免疫学意义和免疫学效应，以及它们在早产条件下的差异。此外，母乳在早产儿肠道定植中发挥的作用，以及为什么这对短期和长期健康结果很重要。
Exposure to the immunologic factors found in maternal breast milk has been shown to compensate for the immature immune system that characterizes the preterm infant. Feeding preterm infants with human milk not only provides protection from disease pathogenesis and ensures an optimal source of nutrients in the short term, but it also helps to ensure the development of a healthy immune response in the long term. Here, we review the immunological significance and antiinflammatory effects of a selection of the bioactive molecules found in human milk and how they may differ under conditions of preterm birth. In addition, the role that human milk plays in the intestinal colonization of the preterm infant and why this is important to short- and long-term health outcomes are discussed.