ARTERIOLAR OXYGEN REACTIVITY - WHERE IS THE SENSOR
ARTERIOLAR OXYGEN REACTIVITY - WHERE IS THE SENSOR
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DOI：
10.1152/ajpheart.1987.253.5.h1120
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发表时间：
1987-11-01
影响因子：
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通讯作者：
JACKSON, WF
中科院分区：
文献类型：
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作者：
JACKSON, WF
通过比较过量使用仓鼠颊袋制剂中小动脉直径对局部和全局PO2变化的响应，验证了小动脉对氧气本质敏感的假设。局部PO2变化是通过在闭塞或未闭塞的肝实质小动脉表面微涂液体或原位插管和灌注小动脉产生的。全局变化是指在整个制备过程中流动的过浓液中PO2的变化。局部有效的PO2变化对小动脉直径无显著影响。相比之下，全球PO2的变化产生了显著的、可重复的直径变化。这些观察结果不支持小动脉本质上对氧敏感的假设，除非氧敏感位点沿着小动脉树稀疏分布。这些数据与位于15微米小动脉下游血管（末端小动脉、毛细血管或小静脉）或实质中的氧传感器一致。这些数据还表明，这些传感器检测到PO2的变化，然后启动反应，这些反应可以沿着脉管系统传导到远离传感器的小动脉。
The hypothesis that arterioles are intrinsically sensitive to oxygen was tested by comparing arteriolar diameter responses with local and global PO2 changes in superfused hamster cheek pouch preparations. Local PO2 changes were produced by microapplication of fluid onto the surface of occluded or unoccluded aparenchymal arterioles or by cannulation and perfusion of arterioles in situ. Global changes refer to PO2 changes in the superfusate flowing over the entire preparation. Local, effective PO2 changes had no significant effect on arteriolar diameters. In contrast, global PO2 changes produced significant, reproducible changes in diameter. These observations do not support the hypothesis that arterioles are intrinsically oxygen sensitive, unless the oxygen-sensitive sites are distributed sparsely along the arteriolar tree. The data are consistent with oxygen sensors located either in vessels downstream from 15-micron arterioles (in terminal arterioles, capillaries, or venules) or in the parenchyma. The data also suggest that these sensors detect changes in PO2 and then initiate responses that can be conducted along the vasculature to an arteriole distant from the sensor.