Salivary proteome and its genetic polymorphisms
Salivary proteome and its genetic polymorphisms
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DOI：
10.1196/annals.1384.030
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Helmerhorst, Eva J.
中科院分区：
文献类型：
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作者：
Oppenheim, Frank G.;Salih, Erdjan;Helmerhorst, Eva J.
口腔和全身性疾病的唾液诊断依赖于识别生物分子，这些生物分子反映了在健康条件下发现的唾液成分的存在、缺失、组成或结构的特征变化。大多数适合诊断的生物标志物包括蛋白质和肽。唾液蛋白对诊断的有用性需要对典型特征的识别，这使得唾液作为一种独特的体液。唾液分泌物反映了一个程度的冗余显示广泛的多态性形成家族的每个主要唾液蛋白。这些多态同工异构体之间的结构差异从明显到细微不等，在某些情况下甚至不会影响不同家庭成员的质量。为了促进现代最先进的蛋白质组学的使用和基于纳米技术的分析方法在诊断领域的发展，主要唾液蛋白家族的显著特征在分子水平上进行了回顾。了解唾液腺来源的蛋白质/肽的结构和功能对快速和正确地识别生物标志物具有重要影响，无论它们是来自外分泌还是非外分泌来源。
Salivary diagnostics for oral as well as systemic diseases is dependent on the identification of biomolecules reflecting a characteristic change in presence, absence, composition, or structure of saliva components found under healthy conditions. Most of the biomarkers suitable for diagnostics comprise proteins and peptides. The usefulness of salivary proteins for diagnostics requires the recognition of typical features, which make saliva as a body fluid unique. Salivary secretions reflect a degree of redundancy displayed by extensive polymorphisms forming families for each of the major salivary proteins. The structural differences among these polymorphic isoforms range from distinct to subtle, which may in some cases not even affect the mass of different family members. To facilitate the use of modern state-of-the-art proteomics and the development of nanotechnology-based analytical approaches in the field of diagnostics, the salient features of the major salivary protein families are reviewed at the molecular level. Knowledge of the structure and function of salivary gland-derived proteins/peptides has a critical impact on the rapid and correct identification of biomarkers, whether they originate from exocrine or non-exocrine sources.