In vivo minimally invasive interstitial multi-functional microendoscopy.
In vivo minimally invasive interstitial multi-functional microendoscopy.
复制标题
体内微创间质多功能显微内窥镜。
DOI：
10.1038/srep01805
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发表时间：
2013
影响因子：
4.6
通讯作者：
Zalevsky,Zeev
中科院分区：
文献类型：
--
作者：
Shahmoon,Asaf;Aharon,Shiran;Kruchik,Oded;Hohmann,Martin;Slovin,Hamutal;Douplik,Alexandre;Zalevsky,Zeev
发展微创的内脏器官成像方法是生物医学检查研究的一个新兴领域。本文介绍了一种新的多功能显微内窥镜设备，能够成像的内部器官与微创干预。此外，所开发的显微内窥镜还可以用作监测装置，用于测量当施用到血管中时血流中的局部血红蛋白浓度。该显微内窥镜设备的总外径仅为200 μm，可提供5,000像素以上的高成像分辨率能力。 该设备可以检测空间分辨率小于1 μm的特征。 微内窥镜已被测试bothin-vitroas和asin-vivoin大鼠提出了一个有前途的和强大的工具，作为一个高分辨率和微创成像设施，适用于以前无法达到的临床模式。
Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200 μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1 μm. The microendoscope has been tested bothin-vitroas well asin-vivoin rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.