A new template to study callosal growth shows specific growth in anterior and posterior regions of the corpus callosum in early childhood.
A new template to study callosal growth shows specific growth in anterior and posterior regions of the corpus callosum in early childhood.
复制标题
研究胼胝体生长的新模板显示了幼儿时期胼胝体前部和后部区域的特定生长。
DOI：
10.1111/ejn.12869
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
BrainDevelopmentCooperativeGroup
中科院分区：
文献类型：
--
作者：
Ansado,Jennyfer;Collins,Louis;Fonov,Vladimir;Garon,Mathieu;Alexandrov,Lubomir;Karama,Sherif;Evans,Alan;Beauchamp,MiriamH;BrainDevelopmentCooperativeGroup
大多数关于胼胝体（CC）发育的研究仅限于对胼胝体面积进行相对简单的评估，提供了CC在两个维度上的大小估计，而不是其实际测量。本研究的目的是通过使用CC的三维（3D）磁共振成像模板重新审视儿童和青少年时期的胼胝体发育，该模板考虑了CC的水平宽度，并将其与二维（2D）胼胝体区域进行比较。我们绘制了一个大样本的青年人胼胝体生长的纵向跟踪（N= 370在T1，N= 304在T2，和N = 246在T3）。这两种技术都基于CC的五部分细分。使用3D方法获得的结果显示，在最年轻的年龄组（< 7岁）中，4年内喙部、前体部、前体部和压部的CC生长率显著高于年龄较大的年龄组，表明CC的前部和后部在儿童早期处于强烈的发育期。当二维胼胝体区域用于CC的前部和后部时，获得了类似的结果。然而，在CC的中间体和尾侧体中发现了不同的结果。正如所示的差异之间的2D估计和实际的3D测量胼胝体生长，我们的研究强调了在测量发展变化的CC考虑水平宽度的重要性。
Most of the studies conducted on the development of the corpus callosum (CC) have been limited to a relatively simple assessment of callosal area, providing an estimation of the size of the CC in two dimensions rather than its actual measurement. The goal of this study was to revisit callosal development in childhood and adolescence by using a three‐dimensional (3D) magnetic resonance imaging template of the CC that considers the horizontal width of the CC and compares this with the two‐dimensional (2D) callosal area. We mapped callosal growth in a large sample of youths followed longitudinally (N= 370 at T1;N= 304 at T2; andN= 246 at T3). Both techniques were based on a five‐section subdivision of the CC. The results obtained with the 3D method revealed that the rate of CC growth over a 4‐year period in the rostrum, the genu, the anterior body and the splenium was significantly higher in the youngest age group (< 7 years) than in older groups, indicating an intense period of development in early childhood for the anterior and posterior parts of the CC. Similar results were obtained when 2D callosal area was used for the anterior and posterior parts of the CC. However, divergent results were found in the mid‐body and the caudal body of the CC. As shown by differences between 2D estimations and actual 3D measurements of callosal growth, our study highlights the importance of considering the horizontal width in measuring developmental changes in the CC.