Sequence characterization of Ndelle virus genome segments 1, 5, 7, 8, and 10:: Evidence for reassignment to the genus Orthoreovirus, family Reoviridae
Sequence characterization of Ndelle virus genome segments 1, 5, 7, 8, and 10:: Evidence for reassignment to the genus Orthoreovirus, family Reoviridae
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DOI：
10.1006/bbrc.2001.5612
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发表时间：
2001-09-21
影响因子：
3.1
通讯作者：
de Lamballerie, X
中科院分区：
文献类型：
--
作者：
Attoui, H;Biagini, P;de Lamballerie, X
对新城疫病毒(NDEV)基因组片段1、5、7、8和10的全长核苷酸序列进行了分析。将推导出的蛋白质氨基酸序列与呼肠孤病毒科其他成员病毒的氨基酸序列进行比较，表明NDEV最初被错误地归入环状病毒属(AA同一性值为<；20%)。相比之下，哺乳动物正病毒(MRV)的氨基酸同源性很高；例如，Gamma3(POL)的氨基酸同源性在91%到97%之间。这些发现与以前的抗原性分析一起提供了证据，表明NDEV应该被重新归类为哺乳动物正病毒物种中的一种新的血清型(指定为MRV-4)。(C)2001年学术出版社。
The full-length nucleotide sequences of genome segments 1, 5, 7, 8 and 10 from Ndelle virus (NDEV) have been characterized. Comparison of the deduced protein amino acid sequences with those of other member viruses of the family Reoviridae demonstrates that NDEV was originally assigned incorrectly to the genus Orbivirus (aa identity values of < 20%). In contrast, high levels of amino acid identity were found with members of the species Mammalian orthoreovirus (MRV); for example, amino acid identity in gamma3(Pol) is between 91 and 97%. These findings, together with previous antigenic analyses, provide evidence that NDEV should be reclassified as a new serotype (designated MRV-4) within the Mammalian orthoreovirus species. (C) 2001 Academic Press.