Membrane photolithography: Direct micropatterning and manipulation of fluid phospholipid membranes in the aqueous phase using deep-UV light

Membrane photolithography: Direct micropatterning and manipulation of fluid phospholipid membranes in the aqueous phase using deep-UV light
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DOI:
10.1002/adma.200306498
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发表时间:
2004-07-19
期刊:
影响因子:
29.4
通讯作者:
Parikh, AN
Parikh, AN
中科院分区:
材料科学1区
文献类型:
--
作者:
Yee, CK;Amweg, ML;Parikh, AN

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使用光激活、局部氧化化学的湿式光刻方法可以直接对浸没在水相中的流体磷脂双层进行图案化。在图案空隙中定向掺入次要成分(见图)可以探测许多膜动力学过程,并可以设计光学定义的孔阵列、功能性膜微结构域和嵌入脂质背景中的蛋白质。
A wet photolithography approach using light-activated, localized oxidative chemistry can directly pattern fluid phospholipid bilayers submerged in aqueous phases. Targeted incorporation of secondary components within pattern voids (see Figure) allows many membrane dynamical processes to be probed and optically defined arrays of holes, functional membrane microdomains, and proteins embedded in a lipidic background can be designed.