Whole Grain Consumption and Breast Cancer: A Case-Control Study in Women
Whole Grain Consumption and Breast Cancer: A Case-Control Study in Women
复制标题
DOI：
10.1080/07315724.2014.963899
复制
发表时间：
2016-02-17
影响因子：
3.5
通讯作者：
Panagiotakos, Demosthenes B.
中科院分区：
文献类型：
--
作者：
Mourouti, Niki;Kontogianni, Meropi D.;Panagiotakos, Demosthenes B.
目的：全谷物消费长期以来一直与人类健康有关。然而，它与乳腺癌的关系仍然没有得到很好的理解和认识。这项工作的目的是评估全谷物消费和女性乳腺癌之间的关联。方法：采用病例对照研究。250例连续的、新诊断的乳腺癌女性患者（56 ± 12岁）和250例年龄匹配的对照者入组。一个标准化的，有效的问卷评估各种社会人口，临床，生活方式和饮食特征，通过面对面的访谈。此外，关于经常食用全谷物的数据（即，从不/很少，1- 6次/周，> 7次/周）。使用MedDietScore（理论范围0-55），通过对地中海饮食的依从性水平评估总体饮食习惯。结果如下：在调整后，每周食用全谷物超过7次与患乳腺癌的可能性降低0.49倍（比值比= 0.49; 95%置信区间，0.29，0.82）相关。结论：这项研究表明，每周食用全谷物超过7次与乳腺癌风险降低相关。
Objective: Whole grain consumption has long been associated with human health. However, its relationship with breast cancer remains not well understood and appreciated. The aim of this work was to evaluate the association between whole grain consumption and breast cancer in women. Methods: A case-control study was designed. Two hundred and fifty consecutive, newly diagnosed breast cancer female patients (56 +/- 12years) and 250 one-to-one age-matched controls were enrolled. A standardized, validated questionnaire assessing various sociodemographic, clinical, lifestyle, and dietary characteristics was applied through face-to-face interviews. Moreover, data on regular consumption of whole grains (i.e., never/rarely, 1-6times/week, >7times/week) were recorded. Overall dietary habits were assessed through the level of adherence to the Mediterranean diet using the MedDietScore (theoretical range 0-55). Results: Whole grain consumption of more than 7times/week was associated with a 0.49-fold (odds ratio = 0.49; 95% confidence interval, 0.29, 0.82) lower likelihood of having breast cancer, after adjustments were made. Conclusions: This study suggested that whole grain consumption more than 7times/week was consistently associated with reduced risk of breast cancer.