Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1
Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1
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DOI：
10.1359/jbmr.050816
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发表时间：
2005-12-01
影响因子：
6.2
通讯作者：
Tanaka, S
中科院分区：
文献类型：
--
作者：
Fukuda, A;Hikita, A;Tanaka, S
利用腺病毒载体表达系统检测了Rac1在破骨细胞存活和骨吸收活性中的作用。Rac1关键参与M-CSF受体信号传导，主要通过PI3K/Akt通路介导生存信号传导。Rac1也在骨吸收活动中发挥重要作用，可能是通过调节破骨细胞的运动。
The role of Rac1 in osteoclast survival and bone-resorbing activity was examined using adenovirus vector expression systems. Rac1 is critically involved in M-CSF receptor signaling and mediates survival signaling primarily through PI3K/Akt pathways. Rac1 also plays a significant role in bone resorptive activity, probably by regulating the motility of osteoclasts.