Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.
Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.
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DOI：
10.3390/cancers9020016
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发表时间：
2017-02-07
期刊：
影响因子：
5.2
通讯作者：
Tolwinski NS
中科院分区：
文献类型：
--
作者：
Lusk JB;Lam VY;Tolwinski NS
EGF信号传导是动物中众所周知的致癌途径。它也是一个关键的发育途径调节终端和背腹图案沿着与胚胎发生的许多其他方面。在这篇综述中，我们专注于不同的作用，表皮生长因子途径在果蝇胚胎发生。我们回顾了现有的身体有关的证据表皮生长因子信号在果蝇胚胎发生目前的不确定性，在该领域和未来的研究领域。本文为利用果蝇模型系统研究EGF对肿瘤的作用提供了基础。
EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer.