Chemical mixtures and children's health.
Chemical mixtures and children's health.
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DOI：
10.1097/mop.0000000000000067
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发表时间：
2014-04
影响因子：
3.6
通讯作者：
Wright RO
中科院分区：
文献类型：
--
作者：
Claus Henn B;Coull BA;Wright RO
人类经常同时或依次暴露于多种化学物质。有证据表明，个别化学品的毒性可能取决于其他化学品的存在。然而，由于缺乏足够的接触数据、统计能力有限以及难以解释多维相互作用，对化学混合物的研究有限。这篇综述总结了最近的文献研究化学混合物和儿科健康的结果，重点是金属混合物。几项研究报告了与儿科健康结果相关的金属之间的显著相互作用。两项前瞻性研究发现了早期铅和锰暴露对认知的交互作用。在两个不同的队列中，铅和镉暴露之间的相互作用对生殖激素水平和神经发育的报告。在加拿大和丹麦的研究中，汞暴露改变了铅暴露对冲动行为和认知的影响。然而，在评估相互作用的接触指标和统计方法方面几乎没有一致性。几项研究表明，金属相互作用对健康的影响不同于单独接触每种金属。尽管可能的化学组合几乎是无限的，但混合物研究代表了真实的生活中的接触情景，值得更多的关注，特别是在特别脆弱的儿童的情况下。
Humans are routinely exposed to multiple chemicals simultaneously or sequentially. There is evidence that the toxicity of individual chemicals may depend on the presence of other chemicals. Studies on chemical mixtures are limited, however, due to lack of sufficient exposure data, limited statistical power, and difficulty in the interpretation of multi-dimensional interactions. This review summarizes the recent literature examining chemical mixtures and pediatric health outcomes, with an emphasis on metal mixtures. Several studies report significant interactions between metals in relation to pediatric health outcomes. Two prospective studies found interactive effects of early life lead and manganese exposures on cognition. In two different cohorts, interactions between lead and cadmium exposures were reported on reproductive hormone levels and on neurodevelopment. Effects of lead exposure on impulsive behavior and cognition were modified by mercury exposure in studies from Canada and Denmark. However, there is little consistency related to exposure indicators and statistical approaches for evaluating interaction. Several studies suggest that metals interact to cause health effects that are different from exposure to each metal alone. Despite the nearly infinite number of possible chemical combinations, mixtures research represents real life exposure scenarios and warrants more attention, particularly in the context of uniquely vulnerable children.