Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age.
Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age.
复制标题
脂蛋白(a)是年轻时发生心肌梗塞的独立危险因素。
作者：
M. Sandkamp;H. Funke;Helmut;Eckhard KOhIer;G. Assmann
我们从前瞻性心血管内科研究（PROCAM）的参与者中招募了年轻（小于46岁）的男性心肌梗死幸存者和年龄匹配的对照组，用免疫化学方法量化了脂蛋白(a) [Lp(a)]。我们进一步测定了载脂蛋白E多态性，并测量了这些受试者血清中的甘油三酯、总胆固醇、高、低密度脂蛋白胆固醇（HDL和LDL）以及载脂蛋白AI、AII和B。血清中Lp(a)浓度与其他已知的早期心肌梗死危险因素（如载脂蛋白AI和B、LDL胆固醇和HDL胆固醇）无关。载脂蛋白E多态性不影响Lp(a)浓度，但对载脂蛋白B浓度有主要影响。Lp(a)浓度不受年龄的影响。我们的数据表明：(a) Lp(a)浓度升高是早期心肌梗死的独立危险因素，(b)血清中Lp(a)和LDL胆固醇（载脂蛋白b）的浓度受到单独的代谢控制。
We quantified lipoprotein(a) [Lp(a)] immunochemically in young (less than 46 y) male survivors of myocardial infarction and in age-matched controls recruited from participants of the Prospective Cardiovascular Münster (PROCAM) study. We further determined apolipoprotein E polymorphism and measured triglycerides, total cholesterol, high- and low-density lipoprotein cholesterol (HDL and LDL), and apolipoproteins AI, AII, and B in the serum of these subjects. Lp(a) concentrations in serum were not correlated with other well-recognized risk factors for early myocardial infarction such as apolipoproteins AI and B, LDL cholesterol, and HDL cholesterol. Apolipoprotein E polymorphism did not affect Lp(a) concentrations, but had a major influence on apolipoprotein B concentration. Lp(a) concentrations were not influenced by age. Our data suggest that (a) an increased concentration of Lp(a) constitutes an independent risk factor for early myocardial infarction and (b) the concentrations of Lp(a) and LDL cholesterol (apolipoprotein B) in serum are under separate metabolic control.
DOI：
10.1073/pnas.84.10.3224
发表时间：
1987-05-01
影响因子：
11.1
作者：
EATON, DL;FLESS, GM;SCANU, AM
通讯作者：
SCANU, AM