EFFECT OF LOW-LEVELS OF FLUORIDE IN SOLUTION ON ENAMEL DEMINERALIZATION INVITRO
EFFECT OF LOW-LEVELS OF FLUORIDE IN SOLUTION ON ENAMEL DEMINERALIZATION INVITRO
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DOI：
10.1177/00220345860650010301
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发表时间：
1986-01-01
影响因子：
7.6
通讯作者：
MURPHY, BJ
中科院分区：
文献类型：
--
作者：
MARGOLIS, HC;MORENO, EC;MURPHY, BJ
研究了低浓度氟化物溶液对离体牙釉质脱矿的影响。将提取的人牙齿暴露于0.1 M乳酸盐溶液（pH 4.3），该溶液相对于釉质矿物质部分饱和，并且含有0.004至1 ppm的氟化物。釉质脱矿采用扫描电镜和偏光显微镜进行监测。据观察，在不存在氟化物的情况下，发生快速釉质脱矿，导致在72小时内形成空化。使用相同的脱矿介质含有低至0.024和0.054 ppm的氟化物，我们观察到一个显着的保护釉质表面。然而，在这些条件下以及在含有0.154 ppm氟化物的溶液中观察到亚表面牙釉质脱矿。当使用含有1ppm氟化物的去矿物质溶液时，没有检测到矿物质损失。所观察到的抑制釉质脱矿也被证明是与一个显着的氟化物的吸收釉质mineral.These观察已被注意到与溶液过饱和度的增加相对于氟化磷灰石物种。所获得的结果被认为是一致的，提出的假设，釉质脱矿的净速率将减少在相对于不太可溶的氟化相过饱和的脱矿介质中，由于氟化磷灰石相的沉淀速率相对于原始釉质表面的溶解速率的增强。
The effect of low levels of fluoride in solution on in vitro enamel demineralization has been studied. Extracted human teeth were exposed to 0.1 M lactate solutions (at pH 4.3) which were partially saturated with respect to enamel mineral and which contained between 0.004 and 1 ppm fluoride. Enamel demineralization was monitored using SEM and polarized light microscopy. It was observed that, in the absence of fluoride, rapid enamel demineralization occurred, resulting in the formation of cavitations within 72 hours. Using the same demineralizing medium containing as little as 0.024 and 0.054 ppm fluoride, we observed a remarkable protection of the enamel surface. Subsurface enamel demineralization was, however, observed under these conditions as well as in a solution containing 0.154 ppm fluoride. When the demineralizing solution containing 1 ppm floride was used, no mineral loss was detected. The observed inhibition of enamel demineralization was also shown to be associated with a significant uptake of fluoride by the enamel mineral. These observations have been noted to correlate with an increase in solution supersaturation with respect to fluoridated apatitic species. The results obtained were found to be consistent with a proposed hypothesis that the net rate of enamel demineralization will be reduced in a demineralizing medium supersaturated with respect to less soluble fluoridated phases, due to the enhancement of the precipitation rate of fluoridated apatitic phases relative to the rate of dissolution of the original enamel surface.