Segmented filamentous bacteria prevent colonization of enteropathogenic Escherichia coli O103 in rabbits
Segmented filamentous bacteria prevent colonization of enteropathogenic Escherichia coli O103 in rabbits
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DOI：
10.1086/315348
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发表时间：
2000-03-01
影响因子：
6.4
通讯作者：
Finlay, BB
中科院分区：
文献类型：
--
作者：
Heczko, U;Abe, A;Finlay, BB
尽管分段丝状细菌（SFB）分布在包括人类在内的许多哺乳动物的肠道中，但尚未在兔子中发现分段丝状细菌（SFB），也没有鉴定出这些不可培养微生物的任何功能。新西兰白兔感染兔致病性大肠杆菌O103（REPEC O103）衍生物，临床随访，接种后1-4天随机处死。通过电子显微镜和光学显微镜检查肠道组织样本，以寻找 SFB 并评估 REPEC O103 定植。 21 只兔子中有 12 只显示回肠吸收性绒毛上有 SFB 定植。SFB 的存在与 REPEC 0103 回肠定植的缺乏 (P < .01) 和疾病相关。没有 SFB 的兔子总是被这种病原体定植，SFB 似乎可以抑制 REPEC O103 的肠道定植，从而防止 REPEC 0103 疾病。还首次描述了 SFB 在兔子体内的定植。
Despite their distribution in the intestines of many mammals, including man, segmented filamentous bacteria (SFB) have not been found in rabbits, nor has any function been identified for these uncultivable microbes. New Zealand White rabbits were infected with rabbit enteropathogenic Escherichia coli O103 (REPEC O103) derivatives, followed up clinically, and randomly killed 1-4 days after inoculation. Intestinal tissue samples were examined by electron and light microscopy to search for SFB and to evaluate REPEC O103 colonization. Twelve of 21 rabbits showed SFB colonization on ileal absorptive villi, The presence of SFB was correlated with lack of REPEC 0103 ileal colonization (P < .01) and disease. Rabbits without SFB were always colonized by this pathogen, SFB appear to inhibit intestinal colonization by REPEC O103 and thus protect against REPEC 0103 disease. SFB colonization in rabbits is also described for the first time.