BORAGE OR PRIMROSE OIL ADDED TO STANDARDIZED DIETS ARE EQUIVALENT SOURCES FOR GAMMA-LINOLENIC ACID IN RATS
BORAGE OR PRIMROSE OIL ADDED TO STANDARDIZED DIETS ARE EQUIVALENT SOURCES FOR GAMMA-LINOLENIC ACID IN RATS
复制标题
DOI：
10.1007/bf02535582
复制
发表时间：
1992-12-01
期刊：
影响因子：
1.9
通讯作者：
MOSER, U
中科院分区：
文献类型：
--
作者：
RAEDERSTORFF, D;MOSER, U
本研究的目的是评估不同剂量和来源的饮食γ-亚麻酸（GLA）对组织磷脂脂肪酸组成的影响。在6周期间，以琉璃苣油或月见报春花油的形式喂食四种不同水平的GLA（2.3、4.6、6.4和16.2 g GLA/kg饮食）的大鼠与喂食玉米油的动物进行比较。二高-γ-亚麻酸（DHLA）和GLA的水平在肝脏、红细胞和主动脉磷脂中显示出显著的剂量相关性增加。此外，随着GLA摄入量的增加，组织中花生四烯酸/DHLA的比例下降。在给予等量饮食GLA（琉璃苣油或月见报春花油）的组内，组织GLA和DHLA水平没有显著差异。饮食GLA管理的量没有显着影响前列腺素E2的生产在刺激的主动脉环和血栓素B2水平在血清中，但是，增加前列腺素E1来自DHLA刺激的主动脉的上清液中观察到。
The aim of this study was to evaluate the effect of different doses and sources of dietary gamma-linolenic acid (GLA) on the tissue phospholipid fatty acid composition. Rats fed four different levels of GLA (2.3, 4.6, 6.4 and 16.2 g of GLA/kg diet) in the form of either borage oil or evening primrose oil during 6 wk were compared with animals fed corn oil. The levels of dihomo-gamma-linolenic acid (DHLA) and GLA showed a significant dose-related increase in liver, erythrocyte and aorta phospholipids. Moreover, the arachidonic acid/DHLA ratios in tissues decreased with increasing intake of dietary GLA. There was no significant difference in tissue GLA and DHLA levels within groups given equal amounts of dietary GLA either as borage oil or evening primrose oil. The amount of dietary GLA administered did not significantly influence prostaglandin E2 production in stimulated aortic rings and thromboxane B2 levels in serum; however, an increase in prostaglandin E1 derived from DHLA was observed in the supernatants of stimulated aorta.