A novel macrolide compound from Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties
A novel macrolide compound from Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties
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DOI：
10.1038/ja.2009.14
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发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Zhang, Ji
中科院分区：
文献类型：
--
作者：
Xiang, Wen-Sheng;Wang, Ji-Dong;Zhang, Ji
天然产物在药物发现中发挥着重要作用，几十年来一直用于治疗疾病。它们构成了用于开发新候选药物的新型分子的主要来源。1-3为了寻找更多的生物活性化合物，我们以前报道过从链霉菌中分离和鉴定米尔贝霉素β13、β14、α28、α29和α30以及裂克米尔贝霉素A和B。4-6本文从S. bingchengensis的分离纯化、结构鉴定和细胞毒活性。
Natural products play an important role in drug discovery and have been used for the treatment of diseases for decades. They constitute a leading source of novel molecules for the development of new drug candidates. 1–3 To search for more bioactive compounds, we have reported earlier the isolation and structure elucidation of milbemycins, β13, β14, α28, α29, and α30, and secomilbemycins A and B from Streptomyces bingchenggensis. 4–6 In this paper, we obtained a novel macrolide compound, ST906 (1), from S. bingchenggensis, and described the fermentation, isolation, structural elucidation and cytotoxic activity.