Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning
Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning
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DOI：
10.1073/pnas.130177397
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发表时间：
2000-06-20
影响因子：
11.1
通讯作者：
Grafman, J
中科院分区：
文献类型：
--
作者：
Koechlin, E;Corrado, G;Grafman, J
众所周知，前额叶前部皮层支持更高的认知功能，如任务管理和计划。然而，人们对人类大脑皮层区域的功能专门化知之甚少。使用功能性MRI，我们报告了双重分离：当受试者按照预期的顺序执行任务时，与腹侧纹状体相关的内侧前额叶皮层优先参与，而当受试者按照不可预测的事件顺序执行任务时，与背外侧纹状体相关的极地前额叶皮层优先参与。这些结果与之前描述的内在和外侧运动前皮层之间的功能分离相似，它们是计划和偶然运动控制的基础，并将这种分离扩展到需要任务管理和计划时的前额叶前部皮层。因此，我们的发现支持了一个假设，即共同的额叶组织原则是人类运动和高级执行功能的基础。
The anterior prefrontal cortex is known to subserve higher cognitive functions such as task management and planning. Less is known, however, about the functional specialization of this cortical region in humans. Using functional MRI, we report a double dissociation: the medial anterior prefrontal cortex, in association with the ventral striatum, was engaged preferentially when subjects executed tasks in sequences that were expected, whereas the polar prefrontal cortex, in association with the dorsolateral striatum, was involved preferentially when subjects performed tasks in sequences that were contingent on unpredictable events. These results parallel the functional segregation previously described between the medial and lateral premotor cortex underlying planned and contingent motor control and extend this division to the anterior prefrontal cortex, when task management and planning are required. Thus, our findings support the assumption that common frontal organizational principles underlie motor and higher executive functions in humans.