Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort
Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort
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DOI：
10.1007/s00125-009-1560-z
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发表时间：
2010-01-01
期刊：
影响因子：
8.2
通讯作者：
Nelson, S. M.
中科院分区：
文献类型：
--
作者：
Lawlor, D. A.;Fraser, A.;Nelson, S. M.
该研究的目的是检查现有糖尿病与（即在妊娠前已诊断）、妊娠期糖尿病和糖尿（在怀孕期间诊断和确定）与出生体重和未来后代BMI，腰围和脂肪量（通过双X射线发射吸收测定法进行评估）。出生队列研究使用来自雅芳父母和孩子纵向研究的数据进行。在10，591对母亲-子女对中，包括出生大小分析，患有糖尿病的妇女（n = 40），那些被诊断患有妊娠期糖尿病的妇女（n = 53）和那些至少有两次++糖尿发作的妇女（n = 372）的平均出生体重和巨大儿的几率（出生体重> 4,000 g）比没有这些症状的妇女要大。对于现有糖尿病、妊娠期糖尿病和糖尿，巨大儿的校正比值比分别为3.56（95%CI 1.53-8.28）、5.50（95%CI 1.18-10.30）和1.58（95%CI 1.18-2.12）。在6，842对9-11岁的母亲-子女中进行人体测量，母亲妊娠期糖尿病和糖尿（但不是现有的糖尿病）与后代总体或中心超重/肥胖的几率增加有关。对于妊娠期糖尿病，这些相关性随着母亲孕前BMI的调整而逐渐减弱，但与糖尿仍有独立的相关性。当比较至少有两次++糖尿发作的女性与没有糖尿病或糖尿证据的女性时，一般超重/肥胖的校正比值比为1.35（95% CI 1.00-1.82）和中心性肥胖（前10%腰围与所有其他人群）的平均值为1.31（95%CI 1.00-1.72）。这些结果为母亲孕期高血压对后代肥胖风险的长期影响提供了一些证据。
The aim of the study was to examine the association of existing diabetes (i.e. already diagnosed prior to pregnancy), gestational diabetes and glycosuria (both diagnosed and ascertained during pregnancy) with birthweight and future offspring BMI, waist circumference and fat mass (assessed by dual x-ray emission absorptiometry).A prospective pregnancy/birth cohort study was performed using data from the Avon Longitudinal Study of Parents and Children.Among 10,591 mother-offspring pairs included in analyses with birth size, women with existing diabetes (n = 40), those diagnosed with gestational diabetes (n = 53) and those with at least two episodes of ++ glycosuria (n = 372) had greater mean birthweight and odds for macrosomia (birthweight > 4,000 g) than women with none of these. Adjusted odds ratios for macrosomia were 3.56 (95% CI 1.53-8.28), 5.50 (95% CI 1.18-10.30) and 1.58 (95% CI 1.18-2.12) for existing diabetes, gestational diabetes and glycosuria, respectively. Among 6,842 mother-offspring pairs with anthropometric measurements at age 9-11 years, maternal gestational diabetes and glycosuria (but not existing diabetes) were associated with increased offspring odds of general or central overweight/obesity. For gestational diabetes, these associations attenuated towards the null with adjustment for maternal prepregnancy BMI, but independent associations remained for glycosuria. The adjusted odds ratio for general overweight/obesity when comparing women with at least two episodes of ++ glycosuria with those with no evidence of diabetes or glycosuria was 1.35 (95% CI 1.00-1.82) and that for central obesity (top 10% waist circumference vs all others) was 1.31 (95% CI 1.00-1.72).These results provide some evidence for a long-term effect of maternal glycaemia in pregnancy on offspring obesity risk.