Common infection-related conditions and risk of lymphoid malignancies in older individuals.
Common infection-related conditions and risk of lymphoid malignancies in older individuals.
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DOI：
10.1038/bjc.2014.173
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发表时间：
2014-05-27
影响因子：
8.8
通讯作者：
Koshiol, J.
中科院分区：
文献类型：
--
作者：
Anderson, L. A.;Atman, A. A.;McShane, C. M.;Titmarsh, G. J.;Engels, E. A.;Koshiol, J.
慢性抗原刺激可启动非霍奇金（NHL）和霍奇金淋巴瘤（HL）的发展。先前，感染相关的条件已被关联，但淋巴细胞增殖亚型的证据是有限的。从美国SEER-Medicare数据库中，选择了44191例NHL、1832例HL和200000例基于人群的对照，与所有SEER癌症病例频率匹配。Logistic回归模型，调整潜在的混杂因素，比较感染相关的条件，在对照与HL和NHL患者和NHL亚型弥漫性大B细胞，T细胞，滤泡和边缘区淋巴瘤（MZL）。按种族进行了分层。呼吸道感染与NHL广泛相关，尤其是MZL。皮肤感染与NHL和大多数NHL亚型的风险增加15-28%相关，特别是蜂窝织炎伴T细胞淋巴瘤（OR 1.36，95%CI 1.24-1.49）。Bonferroni校正后，仅带状疱疹仍与HL相关（OR 1.55，95% CI 1.28-1.87）。胃肠道和泌尿道感染与NHL或HL没有强相关性。在按种族分层分析中，鼻窦炎、咽炎、支气管炎和蜂窝织炎在黑人中与NHL总发病率的相关性强于白人（P<0.001）。感染可能有助于病因学途径和/或潜在的免疫调节的标志物。这些机制的精确阐明可能为理解免疫紊乱如何导致淋巴瘤提供重要线索。
Chronic antigenic stimulation may initiate non-Hodgkin (NHL) and Hodgkin lymphoma (HL) development. Antecedent, infection-related conditions have been associated, but evidence by lymphoproliferative subtype is limited. From the US SEER-Medicare database, 44 191 NHL, 1832 HL and 200 000 population-based controls, frequency-matched to all SEER cancer cases, were selected. Logistic regression models, adjusted for potential confounders, compared infection-related conditions in controls with HL and NHL patients and by the NHL subtypes diffuse large B-cell, T-cell, follicular and marginal zone lymphoma (MZL). Stratification by race was undertaken. Respiratory tract infections were broadly associated with NHL, particularly MZL. Skin infections were associated with a 15–28% increased risk of NHL and with most NHL subtypes, particularly cellulitis with T-cell lymphoma (OR 1.36, 95%CI 1.24–1.49). Only herpes zoster remained associated with HL following Bonferroni correction (OR 1.55, 95% CI 1.28–1.87). Gastrointestinal and urinary tract infections were not strongly associated with NHL or HL. In stratified analyses by race, sinusitis, pharyngitis, bronchitis and cellulitis showed stronger associations with total NHL in blacks than whites (P<0.001). Infections may contribute to the aetiologic pathway and/or be markers of underlying immune modulation. Precise elucidation of these mechanisms may provide important clues for understanding how immune disturbance contributes to lymphoma.
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DOI：
10.1084/jem.20061292
发表时间：
2006-10-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Roulland S;Navarro JM;Grenot P;Milili M;Agopian J;Montpellier B;Gauduchon P;Lebailly P;Schiff C;Nadel B
通讯作者：
Nadel B
带状疱疹与随后的淋巴恶性肿瘤的风险增加有关，这是一项全国性基于人群的基于人群的匹配控制研究。
影响因子：
3.8
作者：
Liu YC;Yang YH;Hsiao HH;Yang WC;Liu TC;Chang CS;Yang MY;Lin PM;Hsu JF;Chang PY;Lin SF
通讯作者：
Lin SF
普通社区获得了感染，随后患慢性淋巴细胞性白血病的风险。
影响因子：
6.5
作者：
Anderson, Lesley A.;Landgren, Ola;Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
2.7
作者：
CARTWRIGHT, RA;MCKINNEY, PA;BIRD, CC
通讯作者：
BIRD, CC
影响因子：
2.8
作者：
Ozsan, Nazan;Cagirgan, Seckin;Hekimgil, Mine
通讯作者：
Hekimgil, Mine