Hybrid Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection or Vaccination Alone.
Hybrid Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection or Vaccination Alone.
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与自然感染或单独接种疫苗相比，怀孕期间对严重急性呼吸系统综合症冠状病毒 2 的混合免疫可提供更持久的婴儿抗体反应。
DOI：
10.1093/infdis/jiae046
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Drak
中科院分区：
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作者：
LaCourse,SylviaM;Wetzler,EricaA;Aurelio,MorganC;Escudero,JaclynN;Selke,StacyS;Greninger,AlexanderL;Goecker,ErinA;Barnes,SarinaR;Arnould,IsabelS;Pérez-Osorio,AilynC;Richardson,BarbraA;Kachikis,Alisa;Englund,JanetA;Drak
laccourse等人在JID发表的一篇论文中发现，在6个月大的婴儿中，与单独感染产生的母源抗体相比，母源对SARS-CoV-2的混合免疫提供了更持久的抗体反应。在此期间，我们还评估了接受过SARS-CoV-2疫苗接种但先前未感染SARS-CoV-2的参与者的样本（仅接种疫苗作为对照）。我们在2021年1月至2022年8月期间招募了107名怀孕期间有SARS-CoV-2感染（入组时抗核衣壳[抗n] IgG+或既往RT-PCR+或抗原+）的参与者（70名混合免疫，37名单独感染），如先前报道的[3]。我们还招募了40名没有sars - cov -2（抗n IgG-）但接种疫苗史（单独接种疫苗的对照组）与胎龄和感染筛查日期相匹配的妊娠对照组。采集分娩/分娩、产后0-< 3和产后3-6个月的血样，采用雅培建筑师（Abbott Architect）检测抗尖峰（抗s） IgG（阳性：≥7.1 BAU/mL）和中和抗体（nAb，血清稀释抑制感染50%[ND50]）。
DOI: 10.1093/infdis/jiae046 2 published paper by LaCourse et al. in JID we found that maternal hybrid immunity to SARS-CoV-2 provided more durable antibody responses compared to maternal antibodies derived from infection alone in infants through 6 months of age [3]. In the interim we have additionally evaluated samples from participants who received SARS-CoV-2 vaccination but without prior SARS-CoV-2 infection (vaccine alone controls).We enrolled 107 participants with prior SARS-CoV-2 infection in pregnancy (anti-nucleocapsid [anti-N] IgG+ on enrollment or prior RT-PCR+ or antigen+) between January 2021-August 2022,(70 with hybrid immunity, 37 with infection alone) as previously reported [3]. We also enrolled 40 pregnant controls without prior SAR-CoV-2 (anti-N IgG-) but history of vaccination (vaccine alone controls) matched by gestational age and date of infection screen. Blood samples collected in delivery/birth, 0-< 3 and 3-6 months postpartum were tested for anti-spike (anti-S) IgG by Abbott Architect (positive:≥ 7.1 BAU/mL) and neutralizing antibodies (nAb, serum dilution inhibited infection by 50%[ND50]).