Use of folic acid supplements in early pregnancy in relation to maternal plasma levels in week 18 of pregnancy
Use of folic acid supplements in early pregnancy in relation to maternal plasma levels in week 18 of pregnancy
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DOI：
10.1002/mnfr.201200116
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发表时间：
2013-04-01
影响因子：
5.2
通讯作者：
Magnus, Per
中科院分区：
文献类型：
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作者：
Roth, Christine;Bjorke-Monsen, Anne L.;Magnus, Per
出生队列通常在妊娠中期测量血浆叶酸，但叶酸补充剂的作用有时仅限于围受孕期。妊娠中期血浆叶酸和围受孕期补充之间的关系尚不清楚。我们比较了妊娠第18周时的血浆叶酸水平与妊娠前至妊娠第17周服用叶酸补充剂的自我报告。方法和结果的样本包括2911名妇女从挪威母亲和儿童队列研究。对于报告从妊娠第4周至第17周连续补充叶酸的女性（N = 238），第18周时的中位血浆叶酸为15.72（nmol/L）。这比报告从第4周至第17周未补充叶酸的女性（N = 844）的血浆叶酸中位数5.67高出约3倍，但仅略高于报告在第1317周补充叶酸的所有女性（N = 1158）的血浆叶酸中位数13.34。在一项针对第8周后继续补充叶酸进行调整的分析中，报告的第8周前补充叶酸与第18周时的血浆叶酸无关。结论：总体而言，我们发现自我报告的叶酸使用与第18周时的血浆叶酸水平之间存在强有力的相关性。我们还发现，第18周时的血浆叶酸并不反映第8周前自我报告的补充。对于围受孕期补充本身，自我报告的数据可能提供更好的衡量标准。
Scope Birth cohorts typically measure plasma folate in midgestation, but effects of folic acid supplementation are sometimes specific to the periconceptional period. The relationship between midgestation plasma folate and periconceptional supplementation is not known. We compared plasma folate at week 18 of gestation with self-report use of supplements comtaining folic acid from before pregnancy to week 17 of gestation. Methods and Results The sample comprised 2911 women from The Norwegian Mother and Child Cohort Study. For women reporting continuous supplementation from gestational week 4 to 17 (N = 238), median plasma folate was 15.72 at week 18 (in nmol/L). This was about threefold higher than the median plasma folate of 5.67 for women reporting no supplementation from week 4 to 17 (N = 844), but only slightly higher than the median plasma folate of 13.34 for all women reporting supplementation in weeks 1317 (N = 1158). Reported supplementation before week 8 was not associated with plasma folate at week 18, in an analysis that adjusted for continued supplementation after week 8. Conclusion Overall we found a strong and coherent relationship between self-reported folic acid use and plasma folate at week 18. We also found that plasma folate at week 18 did not reflect self-reported supplementation before week 8. For periconceptional supplementation per se, self-report data may offer a better measure.