Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential.
Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential.
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DOI：
10.2174/1570159x16666180419141613
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发表时间：
2019
影响因子：
5.3
通讯作者：
Cao M
中科院分区：
文献类型：
--
作者：
Fan D;Liu L;Wu Z;Cao M
翻译后摘要：神经退行性疾病是影响全球数百万人的最严重的健康问题之一。这些疾病的特征在于中枢神经系统中神经元的进行性变性和/或死亡。目前，还没有治疗方法来治愈甚至阻止神经退行性疾病的进展。在过去的二十年里，从天然产物中分离的高效低毒的化合物的神经保护和抗神经退行性变活性受到了广泛的关注。越来越多的证据表明，小檗碱，从传统的中草药中分离的异喹啉生物碱，可能作为一个有前途的抗神经退行性疾病的药物，通过抑制最重要的致病酶的活性，改善细胞内的氧化应激，减轻神经炎症，触发自噬和保护神经元免于凋亡细胞死亡。本文综述了小檗碱对神经退行性疾病的治疗潜力，重点是其对阿尔茨海默氏症，帕金森氏症和亨廷顿氏病的作用的分子机制。
Abstract: Neurodegenerative diseases are among the most serious health problems affecting millions of people worldwide. Such diseases are characterized by a progressive degeneration and / or death of neurons in the central nervous system. Currently, there are no therapeutic approaches to cure or even halt the progression of neurodegenerative diseases. During the last two decades, much attention has been paid to the neuroprotective and anti-neurodegenerative activities of compounds isolated from natural products with high efficacy and low toxicity. Accumulating evidence indicates that berberine, an isoquinoline alkaloid isolated from traditional Chinese medicinal herbs, may act as a promising anti-neurodegenerative agent by inhibiting the activity of the most important pathogenic enzymes, ameliorating intracellular oxidative stress, attenuating neuroinflammation, triggering autophagy and protecting neurons against apoptotic cell death. This review attempts to summarize the current state of knowledge regarding the therapeutic potential of berberine against neurodegenerative diseases, with a focus on the molecular mechanisms that underlie its effects on Alzheimer’s, Parkinson’s and Huntington’s diseases.