Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum
Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum
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DOI：
10.1007/bf02976373
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发表时间：
1999-06-01
影响因子：
6.7
通讯作者：
Kim, YH
中科院分区：
文献类型：
--
作者：
Huong, DTL;Choi, HC;Kim, YH
从前胡根的氯仿提取物中分离得到4种香豆素，经波谱分析鉴定为前胡甲素(1)、花叶毒素(2)、补骨脂素(3)和佛手苷(4)。测定了这些香豆素对小鼠脑内单胺氧化酶的抑制活性。它们的体外IC值分别为27.4、40.7、35.8、13.8。
Four coumarins were isolated from chloroform extract of the root of Peucedanum japonicum and identified as praeruptorin A (1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC, values of them were shown to be 27.4 mu M (1), 40.7 mu M (2), 35.8 mu M (3), and 13.8 mu M (4), in vitro.