Clinical Resistance and Decreased Susceptibility in Streptococcus suis Isolates from Clinically Healthy Fattening Pigs
Clinical Resistance and Decreased Susceptibility in Streptococcus suis Isolates from Clinically Healthy Fattening Pigs
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DOI：
10.1089/mdr.2012.0131
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发表时间：
2013-04-01
影响因子：
2.6
通讯作者：
Boyen, Filip
中科院分区：
文献类型：
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作者：
Callens, Benedicte F.;Haesebrouck, Freddy;Boyen, Filip
猪链球菌（Streptococcus suis，S. suis）是一种重要的猪病原体，被认为是一种新的人畜共患病病原体。因此，重要的是要了解其对抗菌剂的敏感性。在本研究中，已确定了9种抗菌药物对鼻链球菌的最小抑菌浓度（MIC）群体分布。从50个封闭或半封闭猪群的肥育期结束时的健康猪中分离的suis菌株。本研究的目的是报告基于临床折点（临床耐药百分比）和流行病学临界值（非野生型百分比）的耐药性。四环素（98%）、林可霉素（92%）、替米考星（72%）、红霉素（70%）、泰乐菌素（66%）的非野生型百分比较高，氟苯尼考（0%）和恩诺沙星（0.3%）较低。临床耐药率较高的有四环素（95%）、红霉素（66%）、泰乐菌素（66%），较低的有氟苯尼考（0.3%）和恩诺沙星（0.3%）。对于没有临床折点可用的泰妙菌素，57%的分离株不属于野生型群体。青霉素的临床耐药性和非野生型百分比差异很大。只有1%的S.猪流感病毒株被认为具有临床耐药性，而当使用流行病学截断值时，47%的菌株显示获得性耐药性。总之，与以前的报告相比，青霉素的MIC值正在逐渐增加，尽管感染了MIC较高的菌株的猪可能仍然对青霉素治疗有反应。对泰妙菌素的获得性耐药率之高以前未见报道。本研究的结果清楚地表明，使用不同的解释标准有助于报告的抗菌药物耐药性结果的差异程度。早期检测分离株MIC群体分布的微小变化，而可能尚未观察到临床失败，为实施适当的风险管理步骤提供了机会。
Streptococcus suis (S. suis) has often been reported as an important swine pathogen and is considered as a new emerging zoonotic agent. Consequently, it is important to be informed on its susceptibility to antimicrobial agents. In the current study, the Minimum Inhibitory Concentration (MIC) population distribution of nine antimicrobial agents has been determined for nasal S. suis strains, isolated from healthy pigs at the end of the fattening period from 50 closed or semiclosed pig herds. The aim of the study was to report resistance based on both clinical breakpoints (clinical resistance percentage) and epidemiological cutoff values (non-wild-type percentage). Non-wild-type percentages were high for tetracycline (98%), lincomycin (92%), tilmicosin (72%), erythromycin (70%), tylosin (66%), and low for florfenicol (0%) and enrofloxacin (0.3%). Clinical resistance percentages were high for tetracycline (95%), erythromycin (66%), tylosin (66%), and low for florfenicol (0.3%) and enrofloxacin (0.3%). For tiamulin, for which no clinical breakpoint is available, 57% of the isolates did not belong to the wild-type population. Clinical resistance and non-wild-type percentages differed substantially for penicillin. Only 1% of the tested S. suis strains was considered as clinically resistant, whereas 47% of the strains showed acquired resistance when epidemiological cutoff values were used. In conclusion, MIC values for penicillin are gradually increasing, compared to previous reports, although pigs infected with strains showing higher MICs may still respond to treatment with penicillin. The high rate of acquired resistance against tiamulin has not been reported before. Results from this study clearly demonstrate that the use of different interpretive criteria contributes to the extent of differences in reported antimicrobial resistance results. The early detection of small changes in the MIC population distribution of isolates, while clinical failure may not yet be observed, provides the opportunity to implement appropriate risk management steps.