Cause of death and long-term survival in patients with neuro-epithelial brain tumours: a population-based study
Cause of death and long-term survival in patients with neuro-epithelial brain tumours: a population-based study
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DOI：
10.1016/s0959-8049(03)00603-8
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发表时间：
2003-11-01
影响因子：
8.4
通讯作者：
Lote, K
中科院分区：
文献类型：
--
作者：
Johannesen, TB;Langmark, F;Lote, K
与普通人群相比，神经上皮性脑瘤的长期幸存者的死亡率更高，本研究的目的是调查死亡原因，并使用基于人群的材料分析长期生存。在1970年至1993年期间，挪威癌症登记处共登记了6209名患有原发性颅内神经上皮瘤的患者。在一项初步研究中，在临床数据和登记的死因之间发现了高度一致的死因。因此，对整个人口的潜在死亡原因进行了分析。大多数死亡是在确诊后10年内由原发神经上皮性脑瘤引起的。尽管死亡人数很少，但死于其他癌症、血管疾病、感染和事故的患者比例随着时间的推移而继续上升。采用Kaplan-Meier方法计算存活率。在儿童方面，从1970-1981年到1982-1993年，5年、10年和15年的生存率显著提高(分别为47.9、43.6和43.3%比63.8、59.8和59.8%，P
Long-term survivors of neuro-epithelial brain tumours have a higher death rate compared with the general population and the aims of this study were to investigate the causes of death and analyse long-term survival using population-based material. A total of 6209 patients were registered in the period of 1970-1993 with a primary intracranial neuro-epithelial tumour in the The Norwegian Cancer Registry. In a pilot study, a high level of agreement with regard to the cause of death was found between clinical data and the registered cause of death. Underlying causes of death in the whole population were therefore analysed. Most deaths were caused by the primary neuro-epithelial brain tumour within 10 years of diagnosis. Although the numbers were small, the proportion of patients dying from other cancers, vascular disease, infections and accidents continued to rise with time. Survival was computed using the Kaplan-Meier method. For children, survival at 5, 10 and 15 years significantly improved from the time period of 1970-1981 to 1982-1993 (47.9, 43.6 and 43.3% versus 63.8, 59.8 and 59.8%, respectively, P