The function of myeloid-derived suppressor cells in COVID-19 lymphopenia.
The function of myeloid-derived suppressor cells in COVID-19 lymphopenia.
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DOI：
10.1016/j.intimp.2022.109277
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发表时间：
2022-11
影响因子：
5.6
通讯作者：
Cheng, Fanjun
中科院分区：
文献类型：
--
作者：
Li, Taosan;Zheng, Fang;Cheng, Fanjun
2019冠状病毒病（COVID-19）已导致全球大流行，并对公众健康构成重大威胁。淋巴细胞减少症被认为是严重COVID-19的定义特征，尤其是在老年人中。淋巴细胞减少症被认为是疾病严重程度的关键因素。为了最大限度地降低COVID-19患者的死亡率，有必要更深入地了解淋巴细胞减少症背后的过程。最近，骨髓源性抑制细胞（MDSC）已被证实为淋巴细胞减少症的关键介质。MDSC的特征在于其强大的抑制T细胞的能力，并最终促成疾病的进程。靶向这些细胞可以改善疾病预后。本文对MDSCs在淋巴细胞减少症中的研究进行了分析，并讨论了其在COVID-19淋巴细胞减少症患者中的免疫病理变化和前瞻性治疗靶点。
Coronavirus disease 2019 (COVID-19) has caused a global pandemic and presents a significant danger to public health. Lymphopenia is considered to be the defining characteristic of severe COVID-19, especially in elderly people. Lymphopenia has been suggested as a pivotal factor in disease severity. To minimize mortality in COVID-19 patients, it is essential to have a deeper understanding of the processes behind lymphocytopenia. Recently, myeloid-derived suppressor cells (MDSCs) have been confirmed as a key mediator of lymphopenia. MDSCs are characterized by their powerful capacity to suppress T cells and eventually contribute to the course of illness. Targeting these cells may improve the disease prognosis. In this article, we analyze the available research on MDSCs in lymphopenia and discuss their immunopathologic changes and prospective therapeutic targets in patients with COVID-19 lymphocytopenia.
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影响因子：
7.3
作者：
Dean MJ;Ochoa JB;Sanchez-Pino MD;Zabaleta J;Garai J;Del Valle L;Wyczechowska D;Baiamonte LB;Philbrook P;Majumder R;Vander Heide RS;Dunkenberger L;Thylur RP;Nossaman B;Roberts WM;Chapple AG;Wu J;Hicks C;Collins J;Luke B;Johnson R;Koul HK;Rees CA;Morris CR;Garcia-Diaz J;Ochoa AC
通讯作者：
Ochoa AC
影响因子：
12.4
作者：
Agrati, Chiara;Sacchi, Alessandra;Ippolito, Giuseppe
通讯作者：
Ippolito, Giuseppe
影响因子：
30.3
作者：
Guo Q;Zhao Y;Li J;Liu J;Yang X;Guo X;Kuang M;Xia H;Zhang Z;Cao L;Luo Y;Bao L;Wang X;Wei X;Deng W;Wang N;Chen L;Chen J;Zhu H;Gao R;Qin C;Wang X;You F
通讯作者：
You F
DOI：
10.1126/science.abc6261
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arunachalam PS;Wimmers F;Mok CKP;Perera RAPM;Scott M;Hagan T;Sigal N;Feng Y;Bristow L;Tak-Yin Tsang O;Wagh D;Coller J;Pellegrini KL;Kazmin D;Alaaeddine G;Leung WS;Chan JMC;Chik TSH;Choi CYC;Huerta C;Paine McCullough M;Lv H;Anderson E;Edupuganti S;Upadhyay AA;Bosinger SE;Maecker HT;Khatri P;Rouphael N;Peiris M;Pulendran B
通讯作者：
Pulendran B
影响因子：
15.9
作者：
Falck-Jones, Sara;Vangeti, Sindhu;Smed-Sorensen, Anna
通讯作者：
Smed-Sorensen, Anna