Adverse health effects of lead exposure on physical growth, erythrocyte parameters and school performances for school-aged children in eastern China
Adverse health effects of lead exposure on physical growth, erythrocyte parameters and school performances for school-aged children in eastern China
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DOI：
10.1016/j.envint.2020.106130
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发表时间：
2020-12-01
影响因子：
11.8
通讯作者：
Bi, Jun
中科院分区：
文献类型：
--
作者：
Kuang, Wenjie;Chen, Zhaofang;Bi, Jun
我们对中国东部南京市一所公立小学的395名完全匹配的学生样本进行了横断面研究，包括问卷、血液样本、生长指数和学校表现，所有这些都用于方差分析（ANOVA）和一般线性模型（GLM）。结果显示，性别、年龄、父母受教育程度、居住被动吸烟、挑食等因素对血铅水平（BPbs）有显着影响。对于BPbs与红细胞参数之间的线性和非线性剂量反应关系，我们发现BPbs与红细胞计数（RBC计数）和平均红细胞血红蛋白浓度（MCHC）呈正相关，而与血红蛋白（HGB）、红细胞压积（HCT）、平均红细胞体积（MCV）和平均红细胞血红蛋白（MCH）呈负相关。当BPbs增加10μg/L时，男孩的RBC计数增加0.18×10(12)/L，而HGB和HCT分别减少1.19g/L和0.41%。对于女孩，红细胞计数相应增加0.05×10(12)/L，而HGB和HCT分别减少0.82g/L和0.23%。与此同时，男孩和女孩的 MCHC 增加了 2.55 g/L，而 MCV 和 MCH 水平分别减少了 0.41 fL 和 0.12 pg。此外，由于血压b 增加，观察到对儿童的学校表现有显着的不利影响（p < 0.05）。 BPbs每增加10μg/L，孩子的语文、数学、英语成绩分别下降0.42分、0.39分、0.87分。总之，我们的研究表明，铅暴露会对儿童的红细胞参数、体重指数和学校表现产生不利的健康影响。
We conducted a cross-sectional study with 395 completely matched student samples enrolled from a public primary school in Nanjing of eastern China, including questionnaires, blood samples, growth indexes and school performances, all of which were used for the analysis of variance (ANOVA) and general linear model (GLM). The results showed that factors, such as gender, age, parents' education, residential passive smoking and picky eaters, had significant impacts on the blood lead levels (BPbs). As for the linear and non-linear dose-response relationship between BPbs and erythrocyte parameters, we found a positive association between BPbs and red blood cell count (RBC count) and mean corpuscular hemoglobin concentration (MCHC) but a negative association between BPbs and hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). When BPbs increased by 10 mu g/L, the RBC count increased by 0.18 x 10(12)/L, while HGB and HCT decreased by 1.19 g/L and 0.41% for boys, respectively. As for girls, corresponding increases in RBC count was 0.05 x 10(12)/L, while HGB and HCT decreased by 0.82 g/L and 0.23%. Meanwhile, for both boys and girls, MCHC increased by 2.55 g/L, while MCV and MCH levels decreased by 0.41 fL and 0.12 pg each. Furthermore, a remarkable adverse effect (p < 0.05) was observed on children's school performances as a result of increased BPbs. As BPbs increased by 10 mu g/L, children's scores for Chinese, Math and English decreased by 0.42 points, 0.39 points and 0.87 points, respectively. In summary, our study indicated that lead exposure can have adverse health effects on children's erythrocyte parameters, BMI, and school performances.