Traditional Uighur Medicine Karapxa decoction, inhibits liver xanthine oxidase and reduces serum uric acid concentrations in hyperuricemic mice and scavenges free radicals in vitro.
Traditional Uighur Medicine Karapxa decoction, inhibits liver xanthine oxidase and reduces serum uric acid concentrations in hyperuricemic mice and scavenges free radicals in vitro.
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DOI：
10.1186/s12906-015-0644-1
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发表时间：
2015-04-25
影响因子：
--
通讯作者：
Moore N
中科院分区：
文献类型：
--
作者：
Amat N;Umar A;Hoxur P;Anaydulla M;Imam G;Aziz R;Upur H;Kijjoa A;Moore N
卡拉普夏汤是维吾尔族传统药物，用于治疗肝炎、胆囊炎、胃痛、水肿、痛风和关节痛。由于其据称对痛风有作用，因此在酵母膏或氧嗪酸钾诱导的高尿酸血症小鼠模型中测试其作用，以及其体外清除自由基的能力。用酵母膏糊或氧嗪酸钾诱导小鼠高尿酸血症。KD以200、400和800 mg/kg/天剂量经口给药14天，别嘌呤醇10 mg/kg/天作为阳性对照。测定血清尿酸（UA）和肝黄嘌呤氧化酶（XO）活性。体外测定KD对1，1-二苯基-2-苦肼基自由基（DPP·）、一氧化氮（·NO）、超氧阴离子（O2·-）的清除作用、抗脂质过氧化作用和抑制XO的作用。KD抑制高尿酸血症小鼠肝XO活性，降低血清尿酸。KD还表现出明显的抗氧化活性，清除自由基（DPP·，·NO和O2·-）。在体外实验中，它具有抗脂质过氧化和抑制XO的作用。本研究支持传统的使用Karapxa汤治疗高尿酸血症和痛风。
Karapxa decoction (KD) is a Traditional Uighur Medicine used for hepatitis, cholecystitis, gastralgia, oedema, gout and arthralgia. Because of its purported effect in gout, its effects were tested in hyperuricemic mice models induced by yeast extract paste or potassium oxonate, as well as its capacity to scavenge free radicals in vitro. Hyperuricemia was induced in mice by yeast extract paste or potassium oxonate. KD was given orally for 14 days at 200, 400 and 800 mg/kg/day, with Allopurinol 10 mg/kg/day as positive control. Serum uric acid (UA), and liver xanthine oxidase activity (XO) were measured. Scavenging activity of KD on 1, 1-diphenyl-2-picrylhydrazyl radicals (DPP•), nitric oxide (•NO), superoxide (O2•-), efficiency against lipid peroxidation, and XO inhibition were determined in vitro. KD inhibited liver XO activity and reduced serum uric acid in hyperuricemic mice. KD also showed noticeable antioxidant activity, scavenging free radicals (DPP•, •NO and O2•-). It was effective against lipid peroxidation and inhibited XO in vitro. This study supports the traditional use of Karapxa decoction to treat hyperuricemia and gout.
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