Calcium-binding protein-immunoreactive innervation of the rat vibrissa
Calcium-binding protein-immunoreactive innervation of the rat vibrissa
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DOI：
10.1016/s0006-8993(03)02292-3
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发表时间：
2003-04-25
期刊：
影响因子：
2.9
通讯作者：
Sugimoto, T
中科院分区：
文献类型：
--
作者：
Ichikawa, H;Sugimoto, T
免疫组织化学在大鼠触须的小体和默克尔神经末梢中检测到钙结合蛋白（CaBPs）。CaBP免疫反应性（it）小体末梢分为两种类型：分支末梢和无分支末梢。分支末梢又细分为网状末梢和鲁菲尼末梢。无分支末梢与先前描述的纵向披针形末梢相同。网状末梢、无分支末梢以及默克尔末梢共同表达神经钙蛋白（NC）和小白蛋白（PV）免疫反应性（ir）。然而，这些末梢没有肽19（PEP19）免疫反应性。PV免疫反应性鲁菲尼末梢对PEP19有免疫反应，但对NC无免疫反应。逆行追踪法显示，投射到眶下神经的三叉神经元分别有34%、21%和18%呈现NC免疫反应性、PEP19免疫反应性和PV免疫反应性。此外，73%的PV免疫反应性神经元分别显示NC免疫反应性和PEP19免疫反应性。触须低阈值机械感受器中CaBPs的含量和共表达可能取决于它们的末梢形态。（C）2003爱思唯尔科学出版社。保留所有权利。
Immunohistochemistry detected calcium-binding proteins (CaBPs) in corpuscular and Merkel nerve endings of the rat vibrissa. CaBP-immunoreactive (it) corpuscular endings were divided into two types: ramified and unramified endings. Ramified endings were subdivided into reticular and Ruffini endings. Unramified endings were identical to longitudinal lanceolate endings which have been described previously. Reticular and unramified endings as well as Merkel endings co-expressed neurocalcin (NC)- and parvalbumin (PV)-immunoreactivity (ir). However, such endings were devoid of peptide 19 (PEP19)-ir. PV-ir Ruffini endings were immunoreactive for PEP19 but not NC. The retrograde tracing method revealed that 34, 21 and 18% of trigeminal neurons which project to the infraorbital nerve exhibited NC-, PEP19- and PV-ir, respectively. In addition, 73 and 36% of the PV-ir neurons showed NC- and PEP19-ir, respectively. The content and co-expression of CaBPs in vibrissal low-threshold mechanoreceptors may depend on their terminal morphology. (C) 2003 Elsevier Science B.V. All rights reserved.