Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats.
Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats.
复制标题
缬草提取物对睡眠障碍大鼠睡眠-觉醒周期的影响。
DOI：
10.18926/amo/31980
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发表时间：
2005
影响因子：
0.5
通讯作者：
C. Kamei
中科院分区：
文献类型：
--
作者：
K. Shinomiya;Katsuyuki Fujimura;Yonsu Kim;C. Kamei
本研究以睡眠障碍模型大鼠为实验对象，观察了缬草提取物对睡眠-觉醒周期的影响。在1000和3000 mg/kg剂量下，缬草提取物能显著缩短小鼠的睡眠潜伏期。另一方面，即使在3000 mg/kg的剂量下，缬草提取物对清醒、非快速眼动(Non-REM)睡眠或REM睡眠的总次数也没有显著影响。在非快速眼动睡眠中，1000和3000 mg/kg剂量的缬草提取物显著增加了大鼠的Delta活动。综上所述，缬草提取物可能是一种既有催眠作用又有提高睡眠质量作用的中草药。
The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects.