Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides.
Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides.
复制标题
渗透性核苷对人红细胞尿苷流出的反式刺激和反式抑制。
DOI：
10.1042/bj2330295
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Jarvis
中科院分区：
文献类型：
--
作者：
S. Jarvis
比较了核苷渗透物加速尿苷从人红细胞流出的能力。与尿苷相反，2-氯腺苷作为尿苷从新鲜人红细胞流出的反式抑制剂，腺苷几乎没有影响。这些结果与2-氯腺苷和腺苷与尿苷相比流入的最大速度较低一致，并证明反式加速实验不能区分人红细胞核苷载体的转运和非转运渗透物。
The ability of nucleoside permeants to accelerate the efflux of uridine from human erythrocytes has been compared. In contrast to uridine, 2-chloroadenosine acted as a trans-inhibitor of uridine efflux from fresh human erythrocytes, and adenosine had little effect. These results are consistent with the lower maximum velocity for influx of 2-chloroadenosine and adenosine as compared with uridine and demonstrate that trans acceleration experiments do not discriminate between transported and non-transported permeants for the human erythrocyte nucleoside carrier.