Association between symptom severity and internal capsule volume in obsessive-compulsive disorder
Association between symptom severity and internal capsule volume in obsessive-compulsive disorder
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DOI：
10.1016/j.neulet.2009.01.007
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发表时间：
2009-03-06
影响因子：
2.5
通讯作者：
Busatto, Geraldo Filho
中科院分区：
文献类型：
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作者：
de Souza Duran, Fabio Luis;Hoexter, Marcelo Queiroz;Busatto, Geraldo Filho
神经生物学模型支持白色物质束参与强迫症（OCD）的病理生理学，但很少有系统的评价白色物质体积在强迫症使用磁共振成像（MRI）。我们调查了强迫症患者（n = 19）与无症状对照组（n = 15）的扣带束（CB）和内囊前肢（ALIC）体积的潜在差异。使用1.5 T MRI扫描仪评估白色物质体积。在空间归一化和图像分割后，使用优化的基于体素的形态测量学进行组间比较。区域白色物质体积强迫症患者和症状严重程度的相关性也进行了调查。我们发现，与对照组相比，强迫症患者的整体白色物质显著减少。基于体素的区域异常搜索（总白色物质体积的协方差）显示，在OCD（CB和ALIC）中预测的先验受影响的脑部分中没有特定的白色物质体积缺陷。然而，大集群的显着正相关与强迫症的严重程度分数被发现双边的ALIC。这些发现提供了强迫症相关的ALIC异常的证据，并建议在额叶-纹状体-丘脑-皮质电路的连接功能障碍。进一步的研究是必要的，以更好地确定这种白色物质的改变在强迫症的病理生理学的作用，并可能提供线索，更有效地针对神经外科治疗强迫症。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Neurobiological models support an involvement of white matter tracts in the pathophysiology of obsessive-compulsive disorder (OCD), but there has been little systematic evaluation of white matter volumes in OCD using magnetic resonance imaging (MRI). We investigated potential differences in the volume of the cingulum bundle (CB) and anterior limb of internal capsule (ALIC) in OCD patients (n = 19) relative to asymptomatic control subjects (n = 15). White matter volumes were assessed using a 1.5T MRI scanner. Between-group comparisons were carried out after spatial normalization and image segmentation using optimized voxel-based morphometry. Correlations between regional white matter volumes in OCD subjects and symptom severity ratings were also investigated. We found significant global white matter reductions in OCD patients compared to control subjects. The voxel-based search for regional abnormalities (with covariance for total white matter volumes) showed no specific white matter volume deficits in brain portions predicted a priori to be affected in OCD (CB and ALIC). However, large clusters of significant positive correlation with OCD severity scores were found bilaterally on the ALIC. These findings provide evidence of OCD-related ALIC abnormalities and suggest a connectivity dysfunction within frontal-striatal-thalamic-cortical circuits. Further studies are warranted to better define the role of such white matter alterations in the pathophysiology of OCD, and may provide clues for a more effectively targeting of neurosurgical treatments for OCD. (C) 2009 Elsevier Ireland Ltd. All rights reserved.