Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance
Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance
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DOI：
10.1111/j.1748-1716.2008.01909.x
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发表时间：
2009-06-01
影响因子：
6.3
通讯作者：
Tanaka, H.
中科院分区：
文献类型：
--
作者：
Maeda, S.;Sugawara, J.;Tanaka, H.
习惯性有氧运动可显著增加中心动脉顺应性。内皮素-1(ET-1)是一种强大的内皮来源的血管收缩多肽，可能在介导习惯性有氧运动诱导的中心动脉顺应性增加中发挥作用。本研究的目的是探讨ET-1是否参与有氧运动训练增加中央动脉顺应性的机制。7名表面健康的中老年(60+/-3岁)成年人在12周有氧运动训练(最大心率70+/-1%，每天44+/-2分钟)前后分别接受了全身性内皮素-A/B(ET(A/B))受体阻滞剂(500 mg Tracleer((R)，4.4+/-0.1天/周(-1)。运动训练后基础颈动脉顺应性(通过同时进行的B超和颈总动脉压平眼压测量)显著增加。运动训练后静息血浆ET-1浓度显著降低。在运动干预前，给予ET(A/B)受体阻滞剂后，颈动脉顺应性显著增加。然而，训练后，先前通过阻断ET(A/B)受体而观察到的颈动脉顺应性增加在训练前被取消。常规有氧运动训练提高了中老年人的中心动脉顺应性。动脉顺应性的增加与血浆ET-1浓度的相应降低以及ET-1介导的血管张力的消除有关。这些结果表明，ET-1的减少可能是运动训练对中央动脉顺应性产生有利影响的重要机制。
Habitual aerobic exercise results in a significant increase in central arterial compliance. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and could play a role in mediating the habitual aerobic exercise-induced increase in central arterial compliance. The aim of the present study was to examine whether ET-1 is involved in the mechanisms underlying the increase in central arterial compliance with aerobic exercise training.Seven apparently healthy middle-aged and older (60 +/- 3 years) adults underwent systemic endothelin-A/B (ET(A/B))-receptor blockade (500 mg of Tracleer((R))) before and after 12 weeks of aerobic exercise training (70 +/- 1% of maximal heart rate, 44 +/- 2 min day(-1), 4.4 +/- 0.1 days week(-1)).Basal carotid arterial compliance (via simultaneous B-mode ultrasound and arterial applanation tonometry on the common carotid artery) increased significantly after exercise training. Resting plasma ET-1 concentration decreased significantly after exercise training. Before exercise intervention, carotid arterial compliance increased significantly with the administration of the ET(A/B)-receptor blockade. After training, however, increases in carotid arterial compliance previously observed with the ET(A/B)-receptor blockade before training were abolished.Regular aerobic exercise training enhances central arterial compliance in middle-aged and older humans. The increase in arterial compliance was associated with the corresponding reduction in plasma ET-1 concentration as well as the elimination of ET-1-mediated vascular tone. These results suggest that reductions in ET-1 may be an important mechanism underlying the beneficial effect of exercise training on central artery compliance.