Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study.
Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study.
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DOI：
10.1186/1477-5751-12-17
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发表时间：
2013-11-20
期刊：
影响因子：
--
通讯作者：
Takashima Y
中科院分区：
文献类型：
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作者：
Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Hoshino H;Takashima Y
NADH脱氢酶亚基-2-237亮氨酸/甲硫氨酸（ND 2 -237 Leu/Met）多态性与日本人寿命相关先前的研究表明，ND 2 -237 Leu/Met多态性调节绿色茶消费对高血压风险的影响。对于ND 2 - 237 Leu的男性，习惯性饮用绿色茶可能会降低高血压的风险。此外，ND 2 -237 Leu/Met多态性和饮酒对估计肾小球滤过率（eGFR）轻度降低（<90 ml/min/1.73 m2）的风险有联合作用。已经报道了绿色茶对肾脏的几个有益效果。本研究的目的是调查ND 2 -237 Leu/Met多态性是否改变了日本男性健康检查受试者饮用绿色茶对eGFR轻度降低风险的影响。对于ND 2 - 237 Leu基因型男性，在调整混杂因素后，饮用绿色茶可能会增加eGFR轻度降低的风险（趋势P = 0.016）。每天饮用≥6杯绿色茶的ND 2 - 237 Leu受试者中，eGFR轻度降低的调整后比值比（OR）明显高于每天饮用≤1杯绿色茶的受试者（调整后OR = 5.647，95%置信区间：1.528-20.88，P = 0.009）。另一方面，对于ND 2 - 237 Met基因型男性，饮用绿色茶似乎不能确定eGFR轻度降低的风险。目前的研究结果表明，ND 2 -237 Leu/Met多态性意外地改变了日本男性受试者饮用绿色茶对eGFR的影响以及eGFR轻度降低的风险。
NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in Japanese. A previous study has shown that ND2-237 Leu/Met polymorphism modulates the effects of green tea consumption on risk of hypertension. For men with ND2-237Leu, habitual green tea consumption may reduce the risk of hypertension. Moreover, there is a combined effect of ND2-237 Leu/Met polymorphism and alcohol consumption on risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m2). Several beneficial effects of green tea on the kidney have been reported. The objective of this study was to investigate whether ND2-237 Leu/Met polymorphism modifies the effects of green tea consumption on risk of mildly decreased eGFR in male Japanese health check-up examinees. For ND2-237Leu genotypic men, after adjustment for confounding factors, green tea consumption may increase the risk of mildly decreased eGFR (P for trend = 0.016). The adjusted odds ratio (OR) for mildly decreased eGFR was significantly higher in subjects with ND2-237Leu who consume ≥6 cups of green tea per day than those who consume ≤1 cup of green tea per day (adjusted OR = 5.647, 95% confidence interval: 1.528-20.88, P = 0.009). On the other hand, for ND2-237Met genotypic men, green tea consumption does not appear to determine the risk of mildly decreased eGFR. The present results suggest that ND2-237 Leu/Met polymorphism unexpectedly modifies the effects of green tea consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.