The Timed Up and Go test and the ageing heart: Findings from a national health screening of 1,084,875 community-dwelling older adults
The Timed Up and Go test and the ageing heart: Findings from a national health screening of 1,084,875 community-dwelling older adults
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DOI：
10.1177/2047487319882118
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发表时间：
2019-10-20
影响因子：
8.3
通讯作者：
Lee, Sang Chol
中科院分区：
文献类型：
--
作者：
Chun, Sohyun;Shin, Dong Wook;Lee, Sang Chol
目的本研究旨在评估Timed Up and Go测试性能与老年人心脏病发病率和死亡率之间的关系。方法这是一项回顾性队列研究，研究对象为2009-2014年期间参加国家健康筛查计划的1，084，875名老年人（年龄均为66岁）。纳入基线时无心肌梗死、充血性心力衰竭和房颤的参与者，并使用计时启动和启动测试评分将其分为第1组（= 20 s）。终点为心肌梗死、充血性心力衰竭、房颤和全因死亡率。结果在平均3.6年（最长8.0年）的随访中，发生了8885例心肌梗死，10,617例充血性心力衰竭，15,322例心房颤动和22,189例死亡。与第1组参与者相比，第2组和第3组参与者的心肌梗死发生率更高（第3组：校正风险比= 1.40，95%置信区间= 1.11-1.77），充血性心力衰竭（第3组：调整后风险比= 1.59，95%置信区间= 1.31-1.94）和总死亡率（第3组：调整后风险比=1.93，95%置信区间= 1.69-2.20）。在调整多个传统风险因素后，额外风险仍然存在。对于心房颤动，观察到的风险增加的线性趋势与较慢的计时和Go测试速度，但在统计学上是边际的（组3：调整后的风险比=1.17，95%置信区间=0.96-1.44）。结论较慢的计时和Go测试速度与老年人发生心肌梗死，充血性心力衰竭和死亡率的风险增加。
Aim This study aimed to evaluate the relationship between Timed Up and Go test performance and the incidence of older adult heart diseases and mortality.Methods This was a retrospective cohort study of 1,084,875 older adults who participated in a national health screening program between 2009-2014 (all aged 66 years old). Participants free of myocardial infarction, congestive heart failure, and atrial fibrillation at baseline were included and were divided into Group 1 (= 20 s) using the Timed Up and Go test scores. The endpoints were incident myocardial infarction, congestive heart failure, atrial fibrillation, and all-cause mortality. Results During mean follow-up of 3.6 years (maximum 8.0 years), 8885 myocardial infarctions, 10,617 congestive heart failures, 15,322 atrial fibrillations, and 22,189 deaths occurred. Compared with participants in Group 1, Group 2 and Group 3 participants had higher incidences of myocardial infarction (Group 3: adjusted hazard ratio = 1.40, 95% confidence interval = 1.11-1.77), congestive heart failure (Group 3: adjusted hazard ratio = 1.59, 95% confidence interval = 1.31-1.94) and total mortality (Group 3: adjusted hazard ratio=1.93, 95% confidence interval = 1.69-2.20). The additional risks remained after adjusting for multiple conventional risk factors. For atrial fibrillation, a linear trend of increased risk was observed with slower Timed Up and Go test speed, but was statistically marginal (Group 3: adjusted hazard ratio=1.17, 95% confidence interval=0.96-1.44).Conclusion Slower Timed Up and Go test speed is associated with increased risk of developing myocardial infarction, congestive heart failure, and mortality in older adults.