Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse.
Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse.
复制标题
脂肪组织巨噬细胞是由爪诺氏爪蟾和小鼠中骨髓依赖的祖细胞发展而来的。
DOI：
10.1189/jlb.1a0317-082rr
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发表时间：
2017-09
影响因子：
5.5
通讯作者：
Röszer T
中科院分区：
文献类型：
--
作者：
Hassnain Waqas SF;Noble A;Hoang AC;Ampem G;Popp M;Strauß S;Guille M;Röszer T
ATM从早期骨髓祖细胞发育，允许单核细胞非依赖性ATM补充。ATM在哺乳动物中具有代谢影响，因为它们有助于代谢有害的AT炎症。ATM号码的控制可能具有治疗潜力，然而，ATM个体发育的信息是稀缺的。尽管人们认为ATM是从循环单核细胞发育而来的，但各种组织驻留的M β能够自我更新，并在没有单核细胞中间体的情况下从BM非依赖性祖细胞发育而来。在这里，我们表明，两栖动物AT包含自我更新的ATM，在BM造血建立之前填充AT。非洲爪蟾ATM从aVBI的祖细胞发育而来。在小鼠中，大量ATM从卵黄囊中产生，相当于哺乳动物的aVBI。总之，本研究为ATM的产前起源提供了证据，并表明对两栖动物ATM的研究可以增强对产前环境在ATM发育中的作用的理解。
ATMs develop from early myeloid progenitors, allowing monocyte‐independent ATM replenishment. ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue‐resident Mϕs are capable of self‐renewal and develop from BM‐independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self‐renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.