Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7
Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7
复制标题
DOI：
10.1159/000096200
复制
发表时间：
2006-01-01
期刊：
影响因子：
3.4
通讯作者：
Matsunaga, Kayoko
中科院分区：
文献类型：
--
作者：
Yagami, Akiko;Yoshikawa, Tetsushi;Matsunaga, Kayoko
有研究表明，人类疱疹病毒6型（HHV-6）感染的再激活可能参与了药物过敏综合征的发病机制。我们报告一位45岁的日本男性，他出现全身性丘疹性皮疹、发烧、肝炎、淋巴结病和淋巴细胞增多，并伴有非典型淋巴细胞增多。根据实验室数据、斑贴试验结果和主诉的临床病程，他被诊断为盐酸美西律所致DIHS，并接受全身性类固醇治疗。为了确定HHV-6或-7是否与患者的疾病相关，进行了血清学测定和PCR。从第12天到第24天，观察到抗HHV-6和HHV-7的抗体滴度显著增加。从PCR分析，没有外周血单个核细胞或皮肤组织样本含有HHV-6 DNA。然而，所有样本均发现含有HHV-7 DNA。HHV-7的重新激活可能是药物诱导的超敏反应综合征的原因。版权所有（c）2006 S. Karger AG，巴塞尔。
It has been suggested that reactivation of human herpesvirus 6 (HHV-6) infection may be involved in the pathogenesis of drug-induced hypersensitivity syndrome. We report a 45-year-old Japanese man who developed a generalized papuloerythematous rash, fever, hepatitis, lymphadenopathy and lymphocytosis with an increased number of atypical lymphocytes. He was diagnosed with DIHS due to mexiletine hydrochloride based on laboratory data, results of a patch test and the clinical course of his complaint, and was treated with systemic steroids. In order to determine whether HHV-6 or -7 was associated with the patient's disease, serological assays and PCR were carried out. Significant increases in antibody titers against HHV-6 and -7 were observed from day 12 to 24. From PCR analysis, none of the peripheral blood mononuclear cells or skin tissue samples contained HHV-6 DNA. All samples, however, were found to contain HHV-7 DNA. Reactivation of HHV-7 could be responsible for drug-induced hypersensitivity syndrome. Copyright (c) 2006 S. Karger AG, Basel.