IDENTIFICATION OF VERTEBRATE DEEP BRAIN PHOTORECEPTORS
IDENTIFICATION OF VERTEBRATE DEEP BRAIN PHOTORECEPTORS
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DOI：
10.1016/0149-7634(94)90009-4
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发表时间：
1994-12-01
影响因子：
8.2
通讯作者：
GARCIAFERNANDEZ, JM
中科院分区：
文献类型：
--
作者：
FOSTER, RG;GRACE, MS;GARCIAFERNANDEZ, JM
自本世纪初以来，越来越多的证据表明，非哺乳类脊椎动物在大脑深处也有光感受器。这些光感受器涉及几个不同的生理学领域，但在所有研究的物种中，它们在调节昼夜节律和对光的生殖反应中起着关键作用。在过去的50年里，人们做了许多尝试来定位这些感觉细胞，但是直到最近，啊，尝试都失败了。因此，这一重要的感觉系统在很大程度上仍未被探索。最近尝试本地化这些光感受器，在一系列脊椎动物，使用组合抗体和生化方法已经取得了一些成功。然而，出现了不一致的情况。已发表的和初步的数据提出了几种类型的脑感光细胞色素（锥状，棒状或不同的两者）的可能性，并根据物种至少有两种类型的感光细胞：CSF接触神经元（幼虫七鳃鳗，爬行动物和鸟类）和经典的神经分泌神经元内的核magnocellularis preopticus（NMPO）（鱼和两栖动物）。
Since the beginning of this century evidence has accumulated which demonstrates that nonmammalian vertebrates possess photoreceptors situated deep within the brain. These photoreceptors have been implicated in several different areas of physiology, but in all species examined, they play a critical role in the regulation of circadian and reproductive responses to light. Many attempts have been made to localize these sensory cells over the past 50 years, but until recently ah attempts have failed. As a result, this important sensory system remains largely unexplored. Recent attempts to localize these photoreceptors, in a range of vertebrates, using combined antibody and biochemical approaches has met with some success. However, inconsistencies have emerged. Published and preliminary data raise the possibility of several types of encephalic photoreceptor photopigment (cone-like, rod-like or different from both), and depending on species at least two types of photoreceptor cell: CSF-contacting neurons (larval lamprey, reptiles and birds) and classical neurosecretory neurons within the nucleus magnocellularis preopticus (NMPO)(fish and amphibians).