THE ASSOCIATION OF GENE POLYMORPHISMS WITH ATHLETE STATUS IN UKRAINIANS
THE ASSOCIATION OF GENE POLYMORPHISMS WITH ATHLETE STATUS IN UKRAINIANS
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DOI：
10.5604/20831862.1059168
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发表时间：
2013-01-01
期刊：
影响因子：
5.6
通讯作者：
Ilyin, V. N.
中科院分区：
文献类型：
--
作者：
Drozdovska, S. B.;Dosenko, V. E.;Ilyin, V. N.
运动成绩是一个受环境和遗传因素共同影响的多基因性状。目的：调查乌克兰人常见基因多态性与运动员状态的关联。研究方法：共有210名乌克兰精英运动员对100名耐力型运动员和110名力量型运动员和326名对照者进行ACE I/D、HIF 1A Pro582 Ser、NO 53 - 786 T/C、PPARA内含子7 G/C、PPARG Pro 12 Ala和PPARGC 1B Ala 203 Pro基因多态性检测，其中大多数先前报道与运动员状态或不同人群中的相关中间表型相关。结果如下：与对照组相比，力量型运动员的HIF 1A Ser（16.1 vs. 9.4%，P = 0.034）和NOS 3 T等位基因（78.3 vs. 66.2%，P = 0.0019）频率增加。此外，我们发现PPARG Ala等位基因的频率在力量型运动员中显著高于服从型运动员（24.7 vs. 13.5%; P = 0.0076）。接下来，我们确定了运动员和对照组的总基因型得分（TGS，来自三种多态性的累积组合，理论上最佳多基因得分的最大值为100）。力量型运动员的平均TGS显著高于对照组（39.1 +/- 2.3 vs. 32.6 +/- 1.5; P = 0.0142）。结论：我们发现，HIF 1A Ser，NOS 3 T和PPARG Ala等位基因与乌克兰的力量运动员状态。
Athletic performance is a polygenic trait influenced by both environmental and genetic factors. Objective: to investigate individually and in combination the association of common gene polymorphisms with athlete status in Ukrainians. Methods: A total of 210 elite Ukrainian athletes (100 endurance-oriented and 110 power-orientated athletes) and 326 controls were genotyped for ACE I/D, HIF1A Pro582Ser, NO53 -786 T/C, PPARA intron 7 G/C, PPARG Pro12Ala and PPARGC1B Ala203Pro gene polymorphisms, most of which were previously reported to be associated with athlete status or related intermediate phenotypes in different populations. Results: Power-oriented athletes exhibited an increased frequency of the HIF1A Ser (16.1 vs. 9.4%, P = 0.034) and NOS3 T alleles (78.3 vs. 66.2%, P = 0.0019) in comparison with controls. Additionally, we found that the frequency of the PPARG Ala allele was significantly higher in power-oriented athletes compared with the endurance-oriented athletes (24.7 vs. 13.5%; P = 0.0076). Next, we determined the total genotype score (TGS, from the accumulated combination of the three polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in power-oriented athletes (39.1 +/- 2.3 vs. 32.6 +/- 1.5; P = 0.0142) than in controls. Conclusions: We found that the HIF1A Ser, NOS3 T and PPARG Ala alleles were associated with power athlete status in Ukrainians.