Comparison of ventricular pressure relaxation assessments in human heart failure: quantitative influence on load and drug sensitivity analysis.
Comparison of ventricular pressure relaxation assessments in human heart failure: quantitative influence on load and drug sensitivity analysis.
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人类心力衰竭心室压力松弛评估的比较：对负荷和药物敏感性分析的定量影响。
DOI：
10.1016/s0735-1097(99)00362-9
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发表时间：
1999
影响因子：
24
通讯作者：
Kass,DA
中科院分区：
文献类型：
--
作者：
Senzaki,H;Fetics,B;Chen,CH;Kass,DA
目的：我们对比了不同的评估心室压衰减时间常数的方法，以测试心力衰竭是否会系统性地改变对轻微数据不稳定的敏感性或模型假设的衰减与实际衰减之间的差异。我们假设，这种差异可以导致对负荷和药物刺激明显增加的松弛敏感性。背景松弛行为从模型假设的波形可能会因失败而恶化，增强常用指标的不稳定性和表观负荷和药物敏感性。方法测量正常(n=14)、肥厚型(肥厚型心肌病[HCM]，n=15)和扩张型心肌病(扩张型心肌病[DCM]，n=37)患者在负荷降低或肌力刺激前和期间的压力-容量关系。比较松弛参数(假设0-Tlor非零Td的单指数[ME]模型、TF渐近：、混合Logistic-TL、线性-TLR和压力半衰期-T1/2)对轻微的数据范围操纵和加载或药物变化的敏感度。结果在DCM中，TD和TF仅通过删除1-2个数据点而延长了15%至25%(p<；0.0001)，而这对对照组或HCM的影响最小。T1/2和Tln对纯压力补偿高度敏感，而T1/2和Tln对两种操作都最稳定。因此，在扩张型心肌病患者中，TDM和TF对收缩负荷的敏感性明显高于T1/2或T，对环磷酸腺苷(CAMP)的增加不成比例地敏感。结论在DCM患者中，SR松弛持续偏离ME衰变，导致衰竭与对照(或HCM)心脏的ME指标不稳定，并放大了基于ME的收缩负荷或药物依赖性。混合Logistic方法通过提供适用于所有三种心脏类型的更一致的数据来改进定量分析。
OBJECTIVESWe contrasted various methods for assessing ventricular pressure decay time constants to test whether sensitivity to slight data instability or disparities between model-assumed and real decay are systematically altered by cardiac failure. We hypothesized that such discrepancies could result in apparent increased relaxation sensitivity to load and drug stimulation.BACKGROUNDDeviation of relaxation behavior from model-assumed waveforms may be worsened by failure, enhancing instability and apparent load and drug sensitivity of commonly used indexes.METHODSPressure-volume relations were measured in patients with normal (n = 14), hypertrophic (hypertrophic cardiomyopathy [HCM], n = 15) and dilated-myopathic (dilated cardiomyopathy [DCM], n = 37) hearts before and during preload reduction or inotropic stimulation. Relaxation parameters (monoexponential [ME] model assuming zero-Tlnor non-zero-TD, TFasymptote:, hybrid logistic-TL, linear-TLR, and pressure halftime-T1/2) were contrasted regarding sensitivity to slight data range manipulation and loading or drug changes.RESULTSIn DCM,TDandTFprolonged 15% to 25% (p < 0.0001) by deletion of only 1–2 data points, whereas this had minimal effect on controls or HCM. This stemmed from systematic deviation of relaxation from an ME decay in DCM.T1/2andTlnwere highly sensitive to pure pressure offsets, whereasTLwas most stable to both manipulations in all hearts. As a result,TDandTFappeared to be much more sensitive to systolic load in DCM thanT1/2orTLand disproportionately sensitive to increased cyclic adenosine monophosphate (cAMP).CONCLUSIONSRelaxation consistently deviates from an ME decay in DCM resulting in instability and amplified relaxation systolic load or drug dependence of ME-based indexes in failing versus control (or HCM) hearts. The hybrid-logistic method improves quantitative analyses by providing more consistent data fits with all three heart types.
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特发性肥厚型心肌病的动态和被动舒张压-容积关系之间存在显着不一致。
影响因子：
37.8
作者：
Pak,PH;Maughan,L;Baughman,KL;Kass,DA
通讯作者：
Kass,DA
左心室等容舒张 (tau) 时间常数对心包压力的依赖性。
影响因子：
37.8
作者：
M. Frais;D. Bergman;I. Kingma;O. Smiseth;E. Smith;J. Tyberg
通讯作者：
J. Tyberg
正常受试者和扩张型心肌病患者舒张早期左心室流入压。
影响因子：
--
作者：
S. Fujimoto;K. Parker;H. Xiao;K. S. Inge;D. Gibson
通讯作者：
D. Gibson
左心室等容压力-时间曲线的Logistic 表征。
DOI：
10.2170/jjphysiol.45.535
发表时间：
1995
期刊：
The Japanese journal of physiology
影响因子：
--
作者：
H. Matsubara;J. Araki;M. Takaki;S. Nakagawa;H. Suga
通讯作者：
H. Suga
影响因子：
37.8
作者：
Gillebert, TC;LeiteMoreira, AF;DeHert, SG
通讯作者：
DeHert, SG