Salivary anticandidal activity and saliva composition in an HIV-infected cohort
Salivary anticandidal activity and saliva composition in an HIV-infected cohort
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DOI：
10.1034/j.1399-302x.2001.016005270.x
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发表时间：
2001-10-01
影响因子：
--
通讯作者：
Yeh, CK
中科院分区：
文献类型：
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作者：
Lin, AL;Johnson, DA;Yeh, CK
本研究调查了唾液anticandidal活性和唾液成分在刺激的全唾液18个先进的HIV感染者，并比较这些值健康对照。HIV感染患者的刺激性全唾液显示抗念珠菌活性降低。与对照组相比，流速降低了40%。与没有可回收酵母的HIV感染患者相比，唾液中含有可回收酵母的HIV感染患者的唾液流速降低。HIV感染者唾液中乳铁蛋白、分泌型伊加和Cl-浓度升高，而溶菌酶、总蛋白和K+分泌率降低。服用抗真菌药物氟康唑后，任何参数均无差异。唾液anticandidal活性和任何唾液成分之间没有关联。这项研究表明艾滋病毒感染者的抗念珠菌活性和唾液流速降低。这些改变可能导致口腔念珠菌感染的发病率增加。
This study investigated salivary anticandidal activity and salivary composition in stimulated whole saliva of 18 advanced HIV-infected patients and compared these values to healthy controls. Stimulated whole saliva from HIV-infected patients showed decreased anticandidal activity. The flow rate was reduced by 40% as compared with controls. The saliva flow rate for HIV-infected patients who had recoverable yeast in their saliva was reduced as compared to HIV-infected patients without recoverable yeast. For HIV-infected patients, the saliva concentrations of lactoferrin, secretory IgA and Cl- were increased while the secretion rate of lysozyme, total protein and K+ were reduced. There was no difference in any parameter as a function of taking the antifungal drug fluconazole. There was no association between salivary anticandidal activity and any salivary component. This study shows reduced anticandidal activity and salivary flow rate in HIV-infected patients. These alterations may contribute to their increased incidence of oral candidal infections.